Enhancer of polycomb homolog 2

EPC2
Identifiers
Aliases	EPC2, EPC-LIKE, enhancer of polycomb homolog 2
External IDs	OMIM: 611000; MGI: 1278321; GeneCards: EPC2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	148,787,569 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	49,441,960 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; Achilles tendon; ; ganglionic eminence; ; ventricular zone; ; endothelial cell; ; sural nerve; ; bone marrow cell; ; corpus callosum; ; amniotic fluid; ; monocyte;
	Top expressed in
	hand; ; substantia nigra; ; ureter; ; zygote; ; lobe of cerebellum; ; cerebellar vermis; ; medullary collecting duct; ; fossa; ; lateral septal nucleus; ; ventromedial nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone acetyltransferase activity;
Cellular component	nucleus; NuA4 histone acetyltransferase complex; Piccolo NuA4 histone acetyltransferase complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; cellular response to DNA damage stimulus; DNA repair; regulation of transcription by RNA polymerase II; histone acetylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26122
	227867
	ENSG00000135999
	ENSMUSG00000069495
	Q52LR7
	Q8C0I4
	NM_015630
	NM_172663
	NP_056445
	NP_766251
	Wikidata
View/Edit Human	View/Edit Mouse

Enhancer of polycomb homolog 2 is a protein that in humans is encoded by the EPC2 gene.

Function

Predicted to enable protein-macromolecule adaptor activity. Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex and piccolo histone acetyltransferase complex.

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

1 2 3 GRCh38: Ensembl release 89: ENSG00000135999 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069495 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 5 "Entrez Gene: Enhancer of polycomb 2". Retrieved 2026-09-24.

Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J (January 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Molecular Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH (October 2010). "A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs". Cell. 143 (2): 313–24. doi:10.1016/j.cell.2010.09.010. PMC 3018841. PMID 20946988.
Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, Saykin AJ (January 2011). "Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort". Neurology. 76 (1): 69–79. doi:10.1212/WNL.0b013e318204a397. PMC 3030225. PMID 21123754.
Doyon Y, Selleck W, Lane WS, Tan S, Côté J (March 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Molecular and Cellular Biology. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR (April 2010). "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks". Journal of Cell Science. 123 (Pt 7): 1124–30. doi:10.1242/jcs.060178. PMC 2844321. PMID 20332121.
Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. (May 2008). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genetics. 4 (5) e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.
Hayakawa T, Ohtani Y, Hayakawa N, Shinmyozu K, Saito M, Ishikawa F, Nakayama J (June 2007). "RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation". Genes to Cells. 12 (6): 811–26. doi:10.1111/j.1365-2443.2007.01089.x. PMID 17573780. S2CID 10003129.
Guil S, Soler M, Portela A, Carrère J, Fonalleras E, Gómez A, Villanueva A, Esteller M (June 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology. 19 (7): 664–70. doi:10.1038/nsmb.2315. PMID 22659877. S2CID 14906359.
Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC (May 2014). "Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells". Leukemia. 28 (5): 1081–91. doi:10.1038/leu.2013.316. PMC 3998875. PMID 24166297.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135999 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069495 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 4 5 "Entrez Gene: Enhancer of polycomb 2". Retrieved 2026-09-24.

Enhancer of polycomb homolog 2

Function

References

Further reading