EPHA10

EPHA10
Identifiers
Aliases	EPHA10, EPH receptor A10
External IDs	OMIM: 611123; MGI: 3586824; GeneCards: EPHA10
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,765,133 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,917,800 bp
RNA expression pattern
	Top expressed in
	sperm; ; mucosa of transverse colon; ; left testis; ; right testis; ; rectum; ; mucosa of ileum; ; right frontal lobe; ; Brodmann area 9; ; nucleus accumbens; ; epithelium of colon;
	Top expressed in
	piriform cortex; ; primary visual cortex; ; superior colliculus; ; ventral tegmental area; ; superior frontal gyrus; ; pontine nuclei; ; medial vestibular nucleus; ; medial dorsal nucleus; ; dorsal tegmental nucleus; ; inferior colliculi;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; transmembrane-ephrin receptor activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cytoplasm; neuron projection; receptor complex;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; peptidyl-tyrosine phosphorylation; ephrin receptor signaling pathway; biological process; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	284656
	230735
	ENSG00000183317
	ENSMUSG00000028876
	Q5JZY3
	Q8BYG9
	NM_001004338; NM_001099439; NM_173641
	NM_001256432; NM_177671
	NP_001092909; NP_775912
	NP_001243361; NP_808339
	Wikidata
View/Edit Human	View/Edit Mouse

EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene.

Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell–cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183317 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028876 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Aasheim HC, Patzke S, Hjorthaug HS, Finne EF (May 2005). "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis". Biochimica et Biophysica Acta (BBA) - General Subjects. 1723 (1–3): 1–7. doi:10.1016/j.bbagen.2005.01.011. PMID 15777695.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000183317 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028876 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 Aasheim HC, Patzke S, Hjorthaug HS, Finne EF (May 2005). "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis". Biochimica et Biophysica Acta (BBA) - General Subjects. 1723 (1–3): 1–7. doi:10.1016/j.bbagen.2005.01.011. PMID 15777695.