EPS8L2

EPS8L2
Identifiers
Aliases	EPS8L2, EPS8R2, EPS8 like 2, DFNB106
External IDs	OMIM: 614988; MGI: 2138828; GeneCards: EPS8L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWU, 1WXB
Gene location (Human)
Chr.	Chromosome 11 (human)
End	727,727 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,942,933 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; minor salivary glands; ; right lobe of liver; ; right uterine tube; ; mucosa of transverse colon; ; skin of abdomen; ; skin of leg; ; amniotic fluid; ; olfactory zone of nasal mucosa;
	Top expressed in
	intestinal villus; ; esophagus; ; right kidney; ; lip; ; epithelium of small intestine; ; duodenum; ; yolk sac; ; ileum; ; jejunum; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; cadherin binding; protein binding;
Cellular component	ruffle membrane; vesicle; plasma membrane; extracellular exosome; cytoplasm; cytosol; stereocilium bundle; stereocilium tip; stereocilium; protein-containing complex; cell projection;
Biological process	regulation of Rho protein signal transduction; Rho protein signal transduction; positive regulation of ruffle assembly; hearing; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64787
	98845
	ENSG00000177106
	ENSMUSG00000025504
	Q9H6S3
	Q99K30
	NM_022772
	NM_133191
	NP_073609
	NP_573454
	Wikidata
View/Edit Human	View/Edit Mouse

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177106 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025504 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
1 2 "Entrez Gene: EPS8L2 EPS8-like 2".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177106 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025504 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12620401-5] Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.

[entrez-6] 1 2 "Entrez Gene: EPS8L2 EPS8-like 2".

EPS8L2

References

Further reading