ERGIC3 Protein-coding gene in the species Homo sapiens
ERGIC3 Identifiers Aliases ERGIC3 External IDs OMIM : 616971 ; MGI : 1913616 ; GeneCards : ERGIC3 Gene location (Mouse ) Chr. Chromosome 2 (mouse) Band 2 H1| 2 77.32 cM Start 155,849,965 bp End 155,860,199 bp
RNA expression patternBgee Human Mouse (ortholog)Top expressed in right uterine tube right testis left testis stromal cell of endometrium olfactory zone of nasal mucosa right lobe of thyroid gland left lobe of thyroid gland canal of the cervix mucosa of transverse colon left ovary
Top expressed in molar neural layer of retina yolk sac choroid plexus of fourth ventricle right kidney dentate gyrus of hippocampal formation granule cell external carotid artery vestibular sensory epithelium epithelium of lens tail of embryo
More reference expression data
BioGPS
Wikidata
Endoplasmic reticulum-Golgi intermediate compartment protein 3 is a protein that in humans is encoded by the ERGIC3 gene . It has been reported to be regulated by micro RNAs and may be important in a cancer.
It is a member of the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) family.
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000125991 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005881 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Research . 10 (5): 703– 713. doi :10.1101/gr.10.5.703 . PMC 310876 PMID 10810093 . ↑ "Entrez Gene: ERGIC3 ERGIC and golgi 3" .↑ Zhang LY, Liu M, Li X, Tang H (February 2013). "miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3)" . The Journal of Biological Chemistry . 288 (6): 4035– 4047. doi :10.1074/jbc.M112.410506 PMC 3567655 PMID 23212913 . ↑ Lin QH, Zhang KD, Duan HX, Liu MX, Wei WL, Cao Y (October 2015). "ERGIC3, which is regulated by miR-203a, is a potential biomarker for non-small cell lung cancer" . Cancer Science . 106 (10): 1463– 1473. doi :10.1111/cas.12741 PMC 4638005 PMID 26177443 .
Further reading
Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, et al. (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity . 1 : 4. PMID 12747765 . Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, et al. (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46" . The Journal of Biological Chemistry . 279 (45): 47242– 47253. doi :10.1074/jbc.M406644200 PMID 15308636 . Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2005). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Research . 12 (2): 117– 126. doi :10.1093/dnares/12.2.117 PMID 16303743 . Nishikawa M, Kira Y, Yabunaka Y, Inoue M (2007). "Identification and characterization of endoplasmic reticulum-associated protein, ERp43". Gene . 386 (1– 2): 42– 51. doi :10.1016/j.gene.2006.06.030 . PMID 17020792 .
