Epsilon antitoxin

Available protein structures:
PDB	IPR015090 PF08998 (ECOD; PDBsum)
AlphaFold	IPR015090; PF08998;

Bacterial epsilon antitoxin
Bacterial epsilon antitoxin
	crystal structure of the plasmid maintenance system epsilon/zeta: meachnism of toxin inactivation and toxin function
Identifiers
Symbol	Epsilon_antitox
Pfam	PF08998
InterPro	IPR015090
PDB
Available protein structures:
PDB	IPR015090 PF08998 (ECOD; PDBsum)
AlphaFold	IPR015090; PF08998;

In molecular biology, the epsilon antitoxin, produced by various prokaryotes, forms part of a post-segregational killing system, which is involved in the initiation of programmed cell death of plasmid-free cells. The protein is folded into a three-helix bundle that directly interacts with the zeta toxin, inactivating it.

References

↑ Meinhart A, Alonso JC, Strater N, Saenger W (February 2003). "Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1661–6. doi:10.1073/pnas.0434325100. PMC 149889. PMID 12571357.

This article incorporates text from the public domain Pfam and InterPro: IPR015090

[pmid12571357-1] Meinhart A, Alonso JC, Strater N, Saenger W (February 2003). "Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1661–6. doi:10.1073/pnas.0434325100. PMC 149889. PMID 12571357.