Rubin was born and raised in Brockton, Massachusetts. His father, Morris Rubin, was a salesman and his mother, Paula (Schechet) Rubin, was a school librarian. He is married to Akiyo Fujii and has two children, Alexander and Daniel.
Rubin joined the Department of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health in 1999, eventually becoming the Irene Heinz Given Professor and Chair of the Department. His lab studies mycobacterial physiology and virulence and has developed many of the genetic tools used to study Mycobacterium tuberculosis and related organisms. With collaborators, the lab has used these tools to address a wide range of questions about tuberculosis pathogenesis, non-tuberculous mycobacteria, and drug and vaccine development. He is also an infectious disease clinician who sees patients at Brigham and Women’s Hospital, where he is an associate physician.
In 2019, Rubin was appointed editor-in-chief of the journal, where he had previously served as an associate editor, and NEJM Group, the publishing division of the Massachusetts Medical Society. During the COVID-19 outbreak, the journal added a weekly podcast and rapidly published many studies, including the first description of SARS-CoV-2, the causative virus. Under his editorial leadership, NEJM Group launched NEJM Evidence (2022) and NEJM AI (2023), a monthly journal that explores cutting-edge applications of artificial intelligence and machine learning in clinical medicine. He also oversees NEJM Catalyst Innovations in Care Delivery and NEJM Clinician, which launched in December 2025.
Sacks, C. A.; Hardin, C. C.; Normand, S. L.; Kadire, S.; Takvorian, K.; Galloway, N.; Linga, R.; Hannon, P.; Drazen, J.; Rubin, E. (December 22, 2021). "COVID-19 — A Year of Uncertainty and Hope". The New England Journal of Medicine. 386 (2). Massachusetts Medical Society: 182–183. doi:10.1056/NEJMe2118588. PMID35007414. Retrieved December 27, 2024.