RTL8C

RTL8C
Identifiers
Aliases	RTL8C, CXX1, MAR8C, MART8C, Mar8, Mart8, FAM127A, family with sequence similarity 127 member A, SIRH5, retrotransposon Gag like 8C
External IDs	OMIM: 300213; MGI: 1920115; GeneCards: RTL8C
Gene location (Human)
Chr.	X chromosome (human)
End	135,033,546 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	52,610,399 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; right frontal lobe; ; hypothalamus; ; cingulate gyrus; ; anterior cingulate cortex; ; apex of heart; ; amygdala; ; nucleus accumbens; ; left ventricle;
	Top expressed in
	hypothalamus; ; striatum of neuraxis; ; adrenal gland; ; Cortex of frontal lobe; ; cerebellar cortex; ; olfactory bulb; ; superior frontal gyrus; ; hippocampus proper; ; primary visual cortex; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	membrane; plasma membrane; cellular component;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8933
	72865
	ENSG00000134590
	ENSMUSG00000051851
	O15255
	Q9D6I0
	NM_003928; NM_001078171
	NM_028375
	NP_001071639
	NP_082651
	Wikidata
View/Edit Human	View/Edit Mouse

Retrotransposon Gag-like protein 8C is a protein that in humans is encoded by the RTL8C gene (previously FAM127A). An alternative transcription of RTL8C can also produce a longer protein, called CAAX box protein 1. RTL8C is part of a family of at least 11 genes that derive from LTR retrotransposons, but no longer function as retrotransposons.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134590 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051851 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Frattini A, Faranda S, Zucchi I, Vezzoni P (Jan 1998). "A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916)". Genomics. 46 (1): 167–9. doi:10.1006/geno.1997.5006. PMID 9403077.
↑ Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Apr 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene. 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.
↑ Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenet Genome Res. 110 (1–4): 307–17. doi:10.1159/000084963. PMID 16093683. S2CID 38398479.
↑ "Entrez Gene: FAM127A family with sequence similarity 127, member A".
↑ "O15255 · CXX1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.
1 2 "A6ZKI3 · RTL8C_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134590 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051851 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9403077-5] Frattini A, Faranda S, Zucchi I, Vezzoni P (Jan 1998). "A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916)". Genomics. 46 (1): 167–9. doi:10.1006/geno.1997.5006. PMID 9403077.

[pmid15716091-6] Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Apr 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene. 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.

[pmid16093683-7] Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenet Genome Res. 110 (1–4): 307–17. doi:10.1159/000084963. PMID 16093683. S2CID 38398479.

[entrez-8] "Entrez Gene: FAM127A family with sequence similarity 127, member A".

[9] "O15255 · CXX1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

[Uniprot_RTL8C-10] 1 2 "A6ZKI3 · RTL8C_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

RTL8C

References

Further reading