FAM3C

FAM3C
Identifiers
Aliases	FAM3C, ILEI, GS3786, family with sequence similarity 3 member C, FAM3 metabolism regulating signaling molecule C
External IDs	OMIM: 608618; MGI: 107892; GeneCards: FAM3C
Gene location (Human)
Chr.	Chromosome 7 (human)
End	121,396,364 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	22,356,242 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; Achilles tendon; ; pons; ; duodenum; ; lateral nuclear group of thalamus; ; germinal epithelium; ; pericardium; ; vulva; ; endometrium; ; mucosa of sigmoid colon;
	Top expressed in
	neural layer of retina; ; molar; ; semi-lunar valve; ; cumulus cell; ; aortic valve; ; epithelium of stomach; ; ascending aorta; ; Ileal epithelium; ; urothelium; ; mucous cell of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein binding;
Cellular component	extracellular exosome; cytoplasmic vesicle; platelet dense granule lumen; extracellular region; extracellular space; Golgi apparatus;
Biological process	multicellular organism development; platelet degranulation; regulation of signaling receptor activity; biological process; negative regulation of gluconeogenesis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10447
	27999
	ENSG00000196937
	ENSMUSG00000029672
	Q92520
	Q91VU0
	NM_001040020; NM_014888
	NM_138587
	NP_001035109; NP_055703
	NP_613053
	Wikidata
View/Edit Human	View/Edit Mouse

Protein FAM3C is a protein that in humans is encoded by the FAM3C gene.

Function

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Alternate transcriptional splice variants which encode the same protein have been characterized. FAM3C functions and expression also were studied in mammalian brains which shown that a reduced FAM3C level associated to the onset of sporadic Alzheimer's disease (AD), which highlighted FAM3C as a promising therapeutic target for Alzheimer's disease. Moreover, level of FAM3C was claimed to be a biomarker for AD together with saposin D.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196937 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029672 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, et al. (August 2002). "Cloning, expression, and initial characterization of a novel cytokine-like gene family". Genomics. 80 (2): 144–150. doi:10.1006/geno.2002.6816. PMID 12160727.
1 2 "Entrez Gene: FAM3C family with sequence similarity 3, member C".
↑ Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M (June 2014). "The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor". Nature Communications. 5 3917. Bibcode:2014NatCo...5.3917H. doi:10.1038/ncomms4917. PMID 24894631.
↑ Liu L, Watanabe N, Akatsu H, Nishimura M (August 2016). "Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease". Neuroscience. 330: 236–246. doi:10.1016/j.neuroscience.2016.05.050. PMID 27256505. S2CID 24057333.
↑ US patent 7993868, Davies HA, Blennow KS, Mcguire JN, Podust VN, Simonsen AH, Huw Alun, "Saposin D and Fam3c are biomarkers for alzheimer's disease", published 9 Aug 2011, issued 2011-08-09, assigned to Vermillion Inc [Us] and Vermillion, Inc

Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, et al. (July 2004). "Lineage-specific gene duplication and loss in human and great ape evolution". PLoS Biology. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
Mauri P, Scarpa A, Nascimbeni AC, Benazzi L, Parmagnani E, Mafficini A, et al. (July 2005). "Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers". FASEB Journal. 19 (9): 1125–1127. doi:10.1096/fj.04-3000fje. PMID 15985535. S2CID 33940827.
Grønborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, et al. (January 2006). "Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach". Molecular & Cellular Proteomics. 5 (1): 157–171. doi:10.1074/mcp.M500178-MCP200. PMID 16215274.
Guo J, Cheng H, Zhao S, Yu L (January 2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Letters. 580 (2): 581–584. doi:10.1016/j.febslet.2005.12.076. PMID 16406369. S2CID 1013478.
Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, et al. (September 2006). "ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells". Cancer Cell. 10 (3): 227–239. doi:10.1016/j.ccr.2006.07.020. PMID 16959614.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196937 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029672 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Zhu_2002-5] Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, et al. (August 2002). "Cloning, expression, and initial characterization of a novel cytokine-like gene family". Genomics. 80 (2): 144–150. doi:10.1006/geno.2002.6816. PMID 12160727.

[entrez-6] 1 2 "Entrez Gene: FAM3C family with sequence similarity 3, member C".

[7] Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M (June 2014). "The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor". Nature Communications. 5 3917. Bibcode:2014NatCo...5.3917H. doi:10.1038/ncomms4917. PMID 24894631.

[8] Liu L, Watanabe N, Akatsu H, Nishimura M (August 2016). "Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease". Neuroscience. 330: 236–246. doi:10.1016/j.neuroscience.2016.05.050. PMID 27256505. S2CID 24057333.

[9] US patent 7993868, Davies HA, Blennow KS, Mcguire JN, Podust VN, Simonsen AH, Huw Alun, "Saposin D and Fam3c are biomarkers for alzheimer's disease", published 9 Aug 2011, issued 2011-08-09, assigned to Vermillion Inc [Us] and Vermillion, Inc

FAM3C

Function

References

Further reading