Extended synaptotagmin-2

ESYT2

Identifiers

ESYT2, CHR2SYT, E-Syt2, FAM62B, extended synaptotagmin protein 2, extended synaptotagmin 2

External IDs

OMIM: 616691; MGI: 1261845; GeneCards: ESYT2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DMG, 4NPJ, 4NPK, 4P42

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7q36.3	Start	158,730,995 bp
Band	7q36.3	End	158,830,253 bp

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)

Band	12 F2\|12 62.65 cM	Start	116,244,816 bp
Band	12 F2\|12 62.65 cM	End	116,354,670 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

synovial membrane

Achilles tendon

saphenous vein

synovial joint

endothelial cell

urethra

cardiac muscle tissue of right atrium

myocardium of left ventricle

skin of arm

skin of hip

Top expressed in

interventricular septum

decidua

uterus

umbilical cord

ascending aorta

superior cervical ganglion

secondary oocyte

cervix

granulocyte

gastrula

More reference expression data


More reference expression data

Gene ontology
Molecular function	calcium-dependent phospholipid binding calcium ion binding protein binding metal ion binding phosphatidylinositol binding phosphatidylethanolamine binding phosphatidylcholine binding identical protein binding lipid binding cadherin binding
Cellular component	intrinsic component of endoplasmic reticulum membrane organelle membrane contact site integral component of membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane integral component of plasma membrane membrane endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-plasma membrane contact site
Biological process	lipid transport endocytosis glycosphingolipid metabolic process transport endoplasmic reticulum-plasma membrane tethering
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


57488


52635


ENSG00000117868


ENSMUSG00000021171


A0FGR8


Q3TZZ7

RefSeq (mRNA)


NM_020728


NM_028731

RefSeq (protein)


NP_065779 NP_001354702


NP_083007

Location (UCSC)

Chr 7: 158.73 – 158.83 Mb

Chr 12: 116.24 – 116.35 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Extended synaptotagmin-2 is a protein that in humans is encoded by the ESYT2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117868 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021171 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.
↑ "Entrez Gene: FAM62B family with sequence similarity 62 (C2 domain containing) member B".

Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Craxton M (2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.

v t e PDB gallery
2dmg: Solution structure of the third C2 domain of KIAA1228 protein

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