FGL-S

FGL-S
Chemical and physical data
FormulaC47H82N16O18
Molar mass1159.267 g·mol−1
3D model (JSmol)
  • OC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)C)CCC(O)=O)CC(=O)N)CCC(=O)N)CCC(=O)N)CO)CCCCN
  • InChI=InChI=1S/C47H82N16O18/c1-22(2)37(53)46(79)55-23(3)38(71)58-29(13-16-36(69)70)43(76)62-30(19-34(52)67)44(77)61-28(12-15-33(51)66)42(75)60-27(11-14-32(50)65)39(72)54-20-35(68)57-25(9-5-7-17-48)41(74)63-31(21-64)45(78)59-26(10-6-8-18-49)40(73)56-24(4)47(80)81/h22-31,37,64H,5-21,48-49,53H2,1-4H3,(H2,50,65)(H2,51,66)(H2,52,67)(H,54,72)(H,55,79)(H,56,73)(H,57,68)(H,58,71)(H,59,78)(H,60,75)(H,61,77)(H,62,76)(H,63,74)(H,69,70)(H,80,81)/t23-,24-,25-,26-,27-,28-,29-,30-,31-,37-/m0/s1
  • Key:IXCDXKRAQYHCEO-DIGNQEHISA-N

FGL-S (FGLS) is a polypeptide 11 amino acids in length, with the sequence VAENQQGKSKA or Val-Ala-Glu-Asn-Gln-Gln-Gly-Lys-Ser-Lys-Ala. It is a modified fragment derived from the endogenous signalling protein neural cell adhesion molecule, and has antidepressant and anxiolytic effects in animal models.

See also

References

  1. ↑ Bisaz R, Schachner M, Sandi C (January 2011). "Causal evidence for the involvement of the neural cell adhesion molecule, NCAM, in chronic stress-induced cognitive impairments". Hippocampus. 21 (1): 56–71. doi:10.1002/hipo.20723. PMID 19921700.
  2. ↑ Turner CA, Lyons DM, Buckmaster CL, Aurbach EL, Watson SJ, Schatzberg AF, et al. (January 2019). "Neural cell adhesion molecule peptide mimetics modulate emotionality: pharmacokinetic and behavioral studies in rats and non-human primates". Neuropsychopharmacology. 44 (2): 356–363. doi:10.1038/s41386-018-0052-6. PMC 6300554. PMID 29703997.