FIBP

FIBP
Identifiers
Aliases	FIBP, FGFIBP-1, FGF1 intracellular binding protein, TROFAS
External IDs	OMIM: 608296; MGI: 1926233; GeneCards: FIBP
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,888,531 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,515,079 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right frontal lobe; ; prefrontal cortex; ; right hemisphere of cerebellum; ; apex of heart; ; ganglionic eminence; ; left testis; ; right testis; ; Brodmann area 9; ; cingulate gyrus;
	Top expressed in
	lip; ; ventricular zone; ; choroid plexus of fourth ventricle; ; superior frontal gyrus; ; yolk sac; ; primary visual cortex; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; right kidney; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor binding;
Cellular component	extracellular exosome; membrane; mitochondrion; nucleus; endomembrane system; nuclear speck;
Biological process	fibroblast growth factor receptor signaling pathway; platelet aggregation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9158
	58249
	ENSG00000172500
	ENSMUSG00000024911
	O43427
	Q9JI19
	NM_004214; NM_198897
	NM_001253832; NM_021438
	NP_004205; NP_942600
	NP_001240761; NP_067413
	Wikidata
View/Edit Human	View/Edit Mouse

Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.

Function

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

FIBP has been shown to interact with FGF1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172500 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024911 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Kolpakova E, Wiedłocha A, Stenmark H, Klingenberg O, Falnes PO, Olsnes S (November 1998). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor". The Biochemical Journal. 336 (Pt 1): 213–222. doi:10.1042/bj3360213. PMC 1219860. PMID 9806903.
1 2 "Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein". ncbi.nlm.nih.gov.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kolpakova E, Frengen E, Stokke T, Olsnes S (2000). "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein". The Biochemical Journal. 352 (3): 629–635. doi:10.1042/0264-6021:3520629. PMC 1221498. PMID 11104667.
Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, et al. (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". The Journal of Biological Chemistry. 276 (43): 40247–40253. doi:10.1074/jbc.M104933200. PMID 11509569.
Skjerpen CS, Nilsen T, Wesche J, Olsnes S (2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". The EMBO Journal. 21 (15): 4058–4069. doi:10.1093/emboj/cdf402. PMC 126148. PMID 12145206.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172500 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Kolpakova_1998-5] 1 2 Kolpakova E, Wiedłocha A, Stenmark H, Klingenberg O, Falnes PO, Olsnes S (November 1998). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor". The Biochemical Journal. 336 (Pt 1): 213–222. doi:10.1042/bj3360213. PMC 1219860. PMID 9806903.

[entrez-6] 1 2 "Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein". ncbi.nlm.nih.gov.

FIBP

Function

Interactions

References

Further reading