FMNL3

FMNL3
Identifiers
Aliases	FMNL3, FHOD3, WBP-3, WBP3, FRL2, formin like 3
External IDs	OMIM: 616288; MGI: 109569; GeneCards: FMNL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EAH
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,708,165 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,268,363 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; appendix; ; right coronary artery; ; stromal cell of endometrium; ; lymph node; ; Achilles tendon; ; apex of heart; ; granulocyte; ; left coronary artery; ; right lung;
	Top expressed in
	primary oocyte; ; granulocyte; ; calvaria; ; internal carotid artery; ; external carotid artery; ; secondary oocyte; ; zygote; ; endocardial cushion; ; semi-lunar valve; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activating protein binding; actin binding;
Cellular component	cytoplasm; membrane; Golgi apparatus; cytosol; plasma membrane; intracellular membrane-bounded organelle;
Biological process	multicellular organism development; actin cytoskeleton organization; angiogenesis; cellular component organization; cytoskeleton organization; regulation of cell shape; cell migration; cortical actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	91010
	22379
	ENSG00000161791
	ENSMUSG00000023008
	Q8IVF7
	Q6ZPF4
	NM_175736; NM_198900; NM_001367835
	NM_011711; NM_001310622; NM_001310623
	NP_783863; NP_944489; NP_001354764
	NP_001297551; NP_001297552; NP_035841
	Wikidata
View/Edit Human	View/Edit Mouse

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.

Function

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif. FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000161791 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023008 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: formin-like 3".
↑ Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". International Journal of Oncology. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
↑ Heimsath EG, Higgs HN (Jan 2012). "The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends". The Journal of Biological Chemistry. 287 (5): 3087–98. doi:10.1074/jbc.M111.312207. PMC 3270965. PMID 22094460.
↑ Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (Jan 2013). "FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation". Nature Structural & Molecular Biology. 20 (1): 111–8. doi:10.1038/nsmb.2462. PMC 3876896. PMID 23222643.

FMNL3

Function

See also

References

Further reading