FNDC4

FNDC4
Identifiers
Aliases	FNDC4, FRCP1, fibronectin type III domain containing 4
External IDs	OMIM: 611905; MGI: 1917195; GeneCards: FNDC4
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,495,200 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,453,424 bp
RNA expression pattern
	Top expressed in
	left adrenal cortex; ; right adrenal gland; ; right adrenal cortex; ; right lobe of liver; ; right frontal lobe; ; anterior cingulate cortex; ; prefrontal cortex; ; Brodmann area 9; ; nucleus accumbens; ; caudate nucleus;
	Top expressed in
	motor neuron; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; medial dorsal nucleus; ; internal carotid artery; ; external carotid artery; ; facial motor nucleus; ; cerebellar cortex; ; superior frontal gyrus; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	64838
	64339
	ENSG00000115226
	ENSMUSG00000038552
	Q9H6D8
	Q3TR08
	NM_022823
	NM_022424; NM_001356945; NM_001356946; NM_001378890
	NP_073734
	NP_071869; NP_001343874; NP_001343875; NP_001365819
	Wikidata
View/Edit Human	View/Edit Mouse

Fibronectin type III domain-containing protein 4 is a protein that in humans is encoded by the FNDC4 gene. This protein is cleaved into a smaller, secreted protein, soluble FNDC4 (sFNDC4) which activates the receptor ADGRF5 (previously called GPR116), triggering anti-inflammatory effects.

Function

The (long form) of the FNDC4 protein is a single-pass membrane protein, but it can also be cleaved into a secreted, soluble form: sFNDC4. FNDC4 is expressed most highly in the liver and brain, with the liver likely being the main source of sFNDC4 in the body. sFNDC4 signals to various cells and tissues. In the colon, it inhibits inflammatory macrophage activity. In bones, it appears to inhibit the differentiation of osteoclasts, which reduces the amount of bone that the body breaks down.

FNDC4 is also expressed by adipose tissue, functioning as an adipokine. In addition to local anti-inflammatory effects, sFNDC4 has been found to stimulate adipose tissue browning in human fat cells, This effect is mediated by its activation of the ADGRF5 receptor in white fat cells. Based on studies in mice, it is also predicted to increase the insulin sensitivity of fat cells.

Alternative names

FNDC4 has also been called Fibronectin type III repeat-containing protein 1 (FRCP1).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115226 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038552 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 5 6 7 "Fibronectin type III domain-containing protein 4". uniprot.org. UniProt consortium. Retrieved 2026-10-15.
1 2 3 4 Hu YX, Hu C, Hu M, Gao YP, Dong WS, Li K, Ye YJ, Zhang X (2024-05-04). "The role of FNDC4 in inflammation and metabolism for various diseases". Aging and Disease. 16 (3): 1471. doi:10.14336/AD.2024.0381.
↑ Li A, Zhou Z, Li D, Sha P, Hu H, Lin Y, Yue B, Li J, Xiong Y (2025-12-09). "The Molecular Mechanisms of Muscle–Adipose Crosstalk: Myokines, Adipokines, Lipokines and the Mediating Role of Exosomes". Cells. 14 (24): 1954. doi:10.3390/cells14241954.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115226 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038552 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 3 4 5 6 7 "Fibronectin type III domain-containing protein 4". uniprot.org. UniProt consortium. Retrieved 2026-10-15.

[Hu2024-6] 1 2 3 4 Hu YX, Hu C, Hu M, Gao YP, Dong WS, Li K, Ye YJ, Zhang X (2024-05-04). "The role of FNDC4 in inflammation and metabolism for various diseases". Aging and Disease. 16 (3): 1471. doi:10.14336/AD.2024.0381.

[7] Li A, Zhou Z, Li D, Sha P, Hu H, Lin Y, Yue B, Li J, Xiong Y (2025-12-09). "The Molecular Mechanisms of Muscle–Adipose Crosstalk: Myokines, Adipokines, Lipokines and the Mediating Role of Exosomes". Cells. 14 (24): 1954. doi:10.3390/cells14241954.

FNDC4

Function

Alternative names

See also

References