FSCN1

FSCN1

Identifiers

FSCN1, FAN1, HSN, SNL, p55, fascin actin-bundling protein 1

External IDs

OMIM: 602689; MGI: 1352745; GeneCards: FSCN1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1DFC, 4GP0, 4GP3, 3P53, 4GOY, 4GOV, 3LLP

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7p22.1	Start	5,592,816 bp
Band	7p22.1	End	5,606,655 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5 G2\|5 81.84 cM	Start	142,946,098 bp
Band	5 G2\|5 81.84 cM	End	142,958,940 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

ganglionic eminence

middle frontal gyrus

frontal pole

Brodmann area 10

C1 segment

ventricular zone

right frontal lobe

putamen

amygdala

Top expressed in

external carotid artery

internal carotid artery

abdominal wall

Rostral migratory stream

endothelial cell of lymphatic vessel

condyle

primitive streak

endocardial cushion

fossa

mandibular prominence

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein-macromolecule adaptor activity actin filament binding protein binding actin binding RNA binding cadherin binding
Cellular component	cytoplasm cell projection cell-cell junction filopodium ruffle myelin sheath stress fiber microvillus cell junction microspike cell projection membrane actin cytoskeleton podosome extracellular exosome cytoskeleton growth cone lamellipodium filamentous actin cytosol
Biological process	regulation of microvillus assembly establishment of apical/basal cell polarity regulation of actin cytoskeleton organization actin filament organization cell motility positive regulation of podosome assembly actin filament bundle assembly positive regulation of extracellular matrix disassembly cell-cell junction assembly microspike assembly cell population proliferation positive regulation of lamellipodium assembly cell migration positive regulation of filopodium assembly actin cytoskeleton organization anatomical structure morphogenesis establishment or maintenance of cell polarity cytokine-mediated signaling pathway
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


6624


14086


ENSG00000075618


ENSMUSG00000029581


Q16658


Q61553

RefSeq (mRNA)


NM_003088


NM_007984

RefSeq (protein)


NP_003079


NP_032010

Location (UCSC)

Chr 7: 5.59 – 5.61 Mb

Chr 5: 142.95 – 142.96 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Fascin is a protein that in humans is encoded by the FSCN1 gene.

Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor and PKC alpha.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000075618 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029581 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.
↑ Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
↑ "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".
↑ Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
↑ Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.

Further reading

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Yamashiro-Matsumura S, Matsumura F (1985). "Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells". J. Biol. Chem. 260 (8): 5087–97. doi:10.1016/S0021-9258(18)89183-9. PMID 3886649.
Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M (1994). "Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein". J. Virol. 68 (11): 7320–8. doi:10.1128/JVI.68.11.7320-7328.1994. PMC 237173. PMID 7933116.
Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E (1996). "Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein". Am. J. Pathol. 148 (2): 593–600. PMC 1861678. PMID 8579121.
Yamakita Y, Ono S, Matsumura F, Yamashiro S (1996). "Phosphorylation of human fascin inhibits its actin binding and bundling activities". J. Biol. Chem. 271 (21): 12632–8. doi:10.1074/jbc.271.21.12632. PMID 8647875.
Lin XH, Grako KA, Burg MA, Stallcup WB (1997). "NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration". Mol. Biol. Cell. 7 (12): 1977–93. doi:10.1091/mbc.7.12.1977. PMC 276044. PMID 8970159.
Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F (1997). "Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin". J. Biol. Chem. 272 (4): 2527–33. doi:10.1074/jbc.272.4.2527. PMID 8999969.
Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW (1997). "Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. Pathol. 150 (2): 543–62. PMC 1858289. PMID 9033270.
Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB (1998). "The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells". J. Immunol. 160 (8): 3776–82. doi:10.4049/jimmunol.160.8.3776. PMID 9558080.
Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E (1998). "Immunohistochemical study of actin binding protein (p55) in the human kidney". Transplantation. 65 (7): 1004–8. doi:10.1097/00007890-199804150-00025. PMID 9565110.
Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME (2003). "Fascin expression in CD30-positive cutaneous lymphoproliferative disorders". J. Cutan. Pathol. 29 (5): 295–300. doi:10.1034/j.1600-0560.2002.290507.x. PMID 12100631. S2CID 31623792.
Goncharuk VN, Ross JS, Carlson JA (2003). "Actin-binding protein fascin expression in skin neoplasia". J. Cutan. Pathol. 29 (7): 430–8. doi:10.1034/j.1600-0560.2002.290708.x. PMID 12139639. S2CID 26565797.
Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G (2003). "Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer". Br. J. Cancer. 88 (4): 537–47. doi:10.1038/sj.bjc.6600731. PMC 2377175. PMID 12592367.
Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R (2003). "The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer". J. Immunol. 171 (4): 1825–34. doi:10.4049/jimmunol.171.4.1825. PMID 12902483.
Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (2004). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.
Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K (2003). "Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro". J. Neurochem. 87 (3): 676–85. doi:10.1046/j.1471-4159.2003.02058.x. PMID 14535950. S2CID 927239.

v t e PDB gallery
1dfc: CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.