Flonicamid

Flonicamid
Names
	Preferred IUPAC name N-(Cyanomethyl)-4-(trifluoromethyl)pyridine-3-carboxamide
Identifiers
CAS Number	158062-67-0 ;
3D model (JSmol)	Interactive image;
ChemSpider	8010234;
ECHA InfoCard	100.119.736
PubChem CID	9834513;
UNII	9500W2Z53J ;
CompTox Dashboard (EPA)	DTXSID8034611 ;
	InChI InChI=1S/C9H6F3N3O/c10-9(11,12)7-1-3-14-5-6(7)8(16)15-4-2-13/h1,3,5H,4H2,(H,15,16) Key: RLQJEEJISHYWON-UHFFFAOYSA-N;
	SMILES C1=CN=CC(=C1C(F)(F)F)C(=O)NCC#N;
Properties
Chemical formula	C9H6F3N3O
Molar mass	229.162 g/mol
Appearance	White crystalline powder
Odor	none
Density	1.531 at 25 °C
Melting point	157.5 °C (315.5 °F; 430.6 K)
Solubility in water	5.2 g/L at 20 °C
Acidity (pKa)	11.6
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Flonicamid is a synthetic pyridine organic compound used as an insecticide against aphids, whiteflies, and thrips. It disrupts insect chordotonal organs that can affect hearing, balance, movement to cause cessation of feeding, by inhibiting nicotinamidase. It is in IRAC group 29. It is typically sold as wettable granules that are mixed with water before spraying.

Regulation

Products containing this active ingredient have been banned in Denmark because flonicamid can degrade into trifluoroacetic acid, which can then contaminate groundwater and not decompose.

References

1 2 "Flonicamid". sitem.herts.ac.uk. University of Hertfordshire. Retrieved 27 February 2018.
↑ Jeschke, Peter; Witschel, Matthias; Krämer, Wolfgang; Schirmer, Ulrich (25 January 2019). "33.6 Selective Feeding Blockers: Pymetrozine, Flonicamid, and Pyrifluquinazon". Modern Crop Protection Compounds (3rd ed.). Wiley-VCH. pp. 1501–1526. doi:10.1002/9783527699261. ISBN 978-3-527-69926-1.
↑ Qiao, Xiaomu; Zhang, Xiaoyu; Zhou, Zhendong; Guo, Lei (25 November 2022). "An insecticide target in mechanoreceptor neurons". Science Advances. 8 (47) eabq3132. Bibcode:2022SciA....8.3132Q. doi:10.1126/sciadv.abq3132. PMC 9683716. PMID 36417522.
↑ "Modes of Action (MoA) Classification | IRAC". www.irac-online.org. Retrieved 27 February 2018.
↑ "Denmark bans more PFAS pesticides to protect groundwater". Pesticide Action Network Europe. October 6, 2025. Retrieved 6 November 2025.

[Hertsfordshire-1] 1 2 "Flonicamid". sitem.herts.ac.uk. University of Hertfordshire. Retrieved 27 February 2018.

[:0-2] Jeschke, Peter; Witschel, Matthias; Krämer, Wolfgang; Schirmer, Ulrich (25 January 2019). "33.6 Selective Feeding Blockers: Pymetrozine, Flonicamid, and Pyrifluquinazon". Modern Crop Protection Compounds (3rd ed.). Wiley-VCH. pp. 1501–1526. doi:10.1002/9783527699261. ISBN 978-3-527-69926-1.

[3] Qiao, Xiaomu; Zhang, Xiaoyu; Zhou, Zhendong; Guo, Lei (25 November 2022). "An insecticide target in mechanoreceptor neurons". Science Advances. 8 (47) eabq3132. Bibcode:2022SciA....8.3132Q. doi:10.1126/sciadv.abq3132. PMC 9683716. PMID 36417522.

[4] "Modes of Action (MoA) Classification | IRAC". www.irac-online.org. Retrieved 27 February 2018.

[5] "Denmark bans more PFAS pesticides to protect groundwater". Pesticide Action Network Europe. October 6, 2025. Retrieved 6 November 2025.