Fluloprazolam

Fluloprazolam
Clinical data
Other namesFluoprazolam, Floprazolam
Identifiers
  • (2Z)-6-(2-Fluorophenyl)-2-[(4-methylpiperazin-1-yl)methylidene]-8-nitro-4H-imidazo[1,2-a][1,4]benzodiazepin-1-one
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC23H21FN6O3
Molar mass448.458 g·mol−1
3D model (JSmol)
Melting point303–306 °C (577–583 °F)
  • CN1CCN(CC1)/C=C\2/C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5F
  • InChI=InChI=1S/C23H21FN6O3/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24/h2-7,12,14H,8-11,13H2,1H3/b19-14-
  • Key:JYMHWJZLSYFHJD-RGEXLXHISA-N

Fluloprazolam (also known as fluoprazolam) is a benzodiazepine derivative which has been sold online as a designer drug.[citation needed] It is an analog of loprazolam with the chlorine atom on the phenyl group being replaced by a fluorine atom.

History

Fluloprazolam was first described in 1977 by Ager et al.

Pharmacology

Fluloprazolam is expected to have similar pharmacological properties as loprazolam. Its general level of activity has been described as "very high" alongside that of loprazolam. However, fluloprazolam’s dosing range and potency relative to other benzodiazepines has not been described in scientific literature.

Other pharmacological data on fluloprazolam is extremely limited. Little is known about its exact receptor targets, metabolism, and potential toxicity.

References

  1. 1 2 3 Ager IR, Danswan GW, Harrison DR, Kay DP, Kennewell PD, Taylor JB (August 1977). "Central nervous system activity of a novel class of annelated 1,4-benzodiazepines, aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-ones". Journal of Medicinal Chemistry. 20 (8): 1035–1041. doi:10.1021/jm00218a009. PMID 19630.

Notes

  1. ↑ As compared to their parent compounds, which have no halogen on the phenyl group, and have a chlorine atom instead of a nitro group on the benzene ring; IUPAC name (2Z)-6-phenyl-2-[(4-methylpiperazin-1-yl)methylidene]-8-chloro-4H-imidazo[1,2-a][1,4]benzodiazepin-1-one.

See also