Furanosteroid

Furanosteroids are a class of natural chemical compounds that are characterized by a furan ring fused to a typical steroid structure.

Examples of furanosteroids include:

• Wortmannin: a fungal metabolite isolated from Penicillium funiculosum and Talaromyces wortmannii. It is an irreversible PI3K inhibitor widely used as a research tool.
• Viridin: the prototypical example of the class, isolated from Trichoderma species. It has strong antifungal activity.
• Demethoxyviridin: a close viridin analog lacking the methoxy group.
• Viridiol: a reduced form of viridin, produced by Trichoderma virens with herbicidal activity.
• Demethoxyviridiol: a reduced analog of demethoxyviridin.
• Wortmannolone: a wortmannin-related metabolite with a modified ring system.
• 11-Desacetylwortmannin (and related hydroxywortmannins): deacetylated or hydroxylated wortmannin variants.
• Nodulisporiviridins (A–H): a group of viridin-type compounds from Nodulisporium fungi.
• Cyclocalopins: a group of compounds from the bolete mushroom Caloboletus calopus.