GRB2 associated binding protein 3

GAB3
Identifiers
Aliases	GAB3, GRB2 associated binding protein 3
External IDs	OMIM: 300482; MGI: 2387324; GeneCards: GAB3
Gene location (Human)
Chr.	X chromosome (human)
End	154,751,583 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	74,129,064 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; granulocyte; ; apex of heart; ; blood; ; spleen; ; monocyte; ; gonad; ; trabecular bone; ; testicle;
	Top expressed in
	zygote; ; granulocyte; ; stroma of bone marrow; ; blood; ; embryo; ; secondary oocyte; ; embryo; ; Rostral migratory stream; ; spleen; ; thymus;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	139716
	210710
	ENSG00000160219
	ENSMUSG00000032750
	Q8WWW8
	Q8BSM5
	NM_001081573; NM_001282283; NM_080612
	NM_181584
	NP_001075042; NP_001269212; NP_542179
	NP_853615
	Wikidata
View/Edit Human	View/Edit Mouse

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene.

Function

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.