KAT2A

KAT2A
Identifiers
Aliases	KAT2A, GCN5, GCN5L2, PCAF-b, hGCN5, lysine acetyltransferase 2A
External IDs	OMIM: 602301; MGI: 1343101; GeneCards: KAT2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F68, 1Z4R, 3D7C, 5H86, 5H84
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,121,367 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,603,291 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left ovary; ; right ovary; ; right hemisphere of cerebellum; ; right adrenal cortex; ; right frontal lobe; ; left uterine tube; ; left adrenal cortex; ; body of uterus; ; canal of the cervix;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; otic placode; ; tail of embryo; ; otic vesicle; ; saccule; ; genital tubercle; ; epiblast; ; lacrimal gland; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; transcription coactivator activity; N-acetyltransferase activity; transcription factor binding; histone deacetylase binding; chromatin binding; H3 histone acetyltransferase activity; protein binding; acetyltransferase activity; histone acetyltransferase activity (H4-K12 specific); protein phosphatase binding; acyltransferase activity; histone acetyltransferase activity; thiol-dependent deubiquitinase; peptide-lysine-N-acetyltransferase activity; histone succinyltransferase activity;
Cellular component	transcription factor TFTC complex; nucleoplasm; histone acetyltransferase complex; mitotic spindle; extracellular space; nucleus; chromosome; cytoplasm; centrosome; microtubule organizing center; cytoskeleton; oxoglutarate dehydrogenase complex;
Biological process	positive regulation of transcription regulatory region DNA binding; somitogenesis; epigenetic maintenance of chromatin in transcription-competent conformation; chromatin remodeling; metencephalon development; cellular response to nerve growth factor stimulus; regulation of transcription, DNA-templated; regulation of protein stability; response to organic cyclic compound; multicellular organism growth; positive regulation of protein targeting to mitochondrion; regulation of transcription by RNA polymerase II; cardiac muscle cell differentiation; cellular response to tumor necrosis factor; histone H3-K14 acetylation; positive regulation of cell projection organization; in utero embryonic development; transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; positive regulation of histone acetylation; histone deubiquitination; telencephalon development; neural tube closure; response to nutrient levels; regulation of autophagy of mitochondrion; histone acetylation; histone H3 acetylation; cell population proliferation; viral process; intracellular distribution of mitochondria; histone H4-K12 acetylation; alpha-tubulin acetylation; midbrain development; protein deubiquitination; cytokine production; development of the heart; long-term memory; internal peptidyl-lysine acetylation; regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of centriole replication; regulation of synaptic plasticity; regulation of T cell activation; limb development; histone succinylation; positive regulation of cardiac muscle cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2648
	14534
	ENSG00000108773
	ENSMUSG00000020918
	Q92830
	Q9JHD2
	NM_021078; NM_001376227
	NM_001038010; NM_020004
	NP_066564; NP_001363156
	NP_001033099; NP_064388
	Wikidata
View/Edit Human	View/Edit Mouse

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.

KAT2A also acetylates non-histone proteins, including the transcription factor PAX6, promoting its ubiquitination and proteasomal degradation and thereby influencing the balance between proliferation and neuronal differentiation in neural stem cells.