GFM2

GFM2
Identifiers
Aliases	GFM2, EF-G2mt, EFG2, MRRF2, MST027, RRF2, RRF2mt, hEFG2, mEF-G 2, MSTP027, G elongation factor, mitochondrial 2, G elongation factor mitochondrial 2, RRF, GTP dependent ribosome recycling factor mitochondrial 2
External IDs	OMIM: 606544; MGI: 2444783; GeneCards: GFM2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	74,767,147 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	97,317,703 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; tibialis anterior muscle; ; bronchial epithelial cell; ; deltoid muscle; ; epithelium of nasopharynx; ; secondary oocyte; ; mucosa of ileum; ; cardiac muscle tissue of right atrium; ; right uterine tube; ; nasal epithelium;
	Top expressed in
	muscle of thigh; ; otic vesicle; ; sternocleidomastoid muscle; ; otic placode; ; temporal muscle; ; right kidney; ; saccule; ; triceps brachii muscle; ; digastric muscle; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation elongation factor activity; nucleotide binding; GTP binding; protein binding; GTPase activity;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	mitochondrial translational termination; mitochondrial translational elongation; ribosome disassembly; protein biosynthesis; mitochondrial translation; translational elongation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84340
	320806
	ENSG00000164347
	ENSMUSG00000021666
	Q969S9
	Q8R2Q4
	NM_001281302; NM_032380; NM_170681; NM_170691
	NM_001146043; NM_001271463; NM_001271464; NM_001271465; NM_177266
	NP_001268231; NP_115756; NP_733781; NP_733792; NP_733792.1
	NP_001139515; NP_001258392; NP_001258393; NP_001258394; NP_796240
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164347 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021666 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.
↑ "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".
↑ Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi:10.1016/j.molcel.2009.06.028. PMID 19716793.

External links

InterPro: IPR030851

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164347 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021666 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11735030-5] Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.

[entrez-6] "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".

[7] Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi:10.1016/j.molcel.2009.06.028. PMID 19716793.