GNPDA2

GNPDA2

Identifiers

GNPDA2, GNP2, SB52, glucosamine-6-phosphate deaminase 2

External IDs

OMIM: 613222; MGI: 1915230; GeneCards: GNPDA2

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
3.5.99.6	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 4 (human)

Band	4p12	Start	44,682,200 bp
Band	4p12	End	44,726,588 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 C3.1	Start	69,730,451 bp
Band	5\|5 C3.1	End	69,749,683 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

Achilles tendon

ventricular zone

islet of Langerhans

ganglionic eminence

smooth muscle tissue

cerebellar hemisphere

right hemisphere of cerebellum

Brodmann area 9

Descending thoracic aorta

Top expressed in

spermatid

olfactory epithelium

zygote

secondary oocyte

lumbar spinal ganglion

atrioventricular valve

primary oocyte

lateral septal nucleus

ventromedial nucleus

seminiferous tubule

More reference expression data

n/a

Gene ontology
Molecular function	protein binding hydrolase activity glucosamine-6-phosphate deaminase activity identical protein binding
Cellular component	nucleus cytosol cytoplasm
Biological process	N-acetylglucosamine metabolic process glucosamine catabolic process carbohydrate metabolic process N-acetylglucosamine catabolic process UDP-N-acetylglucosamine biosynthetic process N-acetylneuraminate catabolic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


132789


67980


ENSG00000163281


ENSMUSG00000029209


Q8TDQ7


Q9CRC9

RefSeq (mRNA)


NM_001270880 NM_001270881 NM_138335


NM_001038015 NM_027681 NM_001347363 NM_001359239

RefSeq (protein)


NP_001257809 NP_001257810 NP_612208


NP_001033104 NP_001334292 NP_001346168

Location (UCSC)

Chr 4: 44.68 – 44.73 Mb

Chr 5: 69.73 – 69.75 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Glucosamine-6-phosphate deaminase 2 also known as GNPDA2 is an enzyme that in humans is encoded by the GNPDA2 gene.

Clinical significance

Variants of the GNPDA2 gene may be associated with obesity.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163281 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029209 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Arreola R, Valderrama B, Morante ML, Horjales E (September 2003). "Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study". FEBS Lett. 551 (1–3): 63–70. doi:10.1016/S0014-5793(03)00896-2. PMID 12965206. S2CID 45050024.
↑ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring). 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782. PMID 19478790.
↑ Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.
↑ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 25–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261.

Further reading

Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference". Am. J. Clin. Nutr. 90 (4): 951–9. doi:10.3945/ajcn.2009.27781. PMID 19692490.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study". Obesity (Silver Spring). 18 (6): 1212–7. doi:10.1038/oby.2009.413. PMID 19910938. S2CID 9601431.
Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies". Am. J. Clin. Nutr. 91 (1): 184–90. doi:10.3945/ajcn.2009.28403. PMID 19812171.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
Renström F, Payne F, Nordström A, et al. (2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.
He M, Cornelis MC, Franks PW, et al. (2010). "Obesity Genotype Score and Cardiovascular Risk in Women with Type 2 Diabetes". Arterioscler. Thromb. Vasc. Biol. 30 (2): 327–32. doi:10.1161/ATVBAHA.109.196196. PMC 3061473. PMID 19910641.
Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population". J. Hum. Genet. 54 (12): 727–31. doi:10.1038/jhg.2009.106. PMID 19851340.

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