GPLD1

GPLD1
Identifiers
Aliases	GPLD1, GPIPLD, GPIPLDM, PIGPLD, PIPLD, glycosylphosphatidylinositol specific phospholipase D1
External IDs	OMIM: 602515; MGI: 106604; GeneCards: GPLD1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	24,495,205 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	25,176,484 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; human penis; ; liver; ; buccal mucosa cell; ; right lobe of liver; ; right hemisphere of cerebellum; ; skin of thigh; ; testicle; ; gonad; ; Descending thoracic aorta;
	Top expressed in
	left lobe of liver; ; utricle; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; transitional epithelium of urinary bladder; ; mammillary body; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus; ; esophagus; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sodium channel regulator activity; phospholipase D activity; glycosylphosphatidylinositol phospholipase D activity; hydrolase activity;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; intracellular anatomical structure; lysosomal membrane; extracellular exosome; extracellular region; extracellular space; extracellular matrix;
Biological process	cellular response to calcium ion; insulin receptor signaling pathway; positive regulation of triglyceride biosynthetic process; positive regulation of high-density lipoprotein particle clearance; chondrocyte differentiation; ossification; cellular response to triglyceride; hematopoietic stem cell migration to bone marrow; positive regulation of membrane protein ectodomain proteolysis; positive regulation of glucose metabolic process; hematopoietic stem cell migration; response to glucose; cellular response to cholesterol; cell migration involved in sprouting angiogenesis; transepithelial transport; positive regulation of endothelial cell migration; GPI anchor release; positive regulation of cytolysis; cellular response to pH; positive regulation of secretion; regulation of cellular response to insulin stimulus; positive regulation of alkaline phosphatase activity; cellular response to insulin stimulus; complement receptor mediated signaling pathway; positive regulation of apoptotic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of triglyceride catabolic process; phosphatidylcholine metabolic process; negative regulation of cell population proliferation; C-terminal protein lipidation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2822
	14756
	ENSG00000112293
	ENSMUSG00000021340
	P80108
	O70362
	NM_001503; NM_177483
	NM_008156
	NP_001494
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene.

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by the GPLD1 gene is a GPI degrading enzyme that hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.

Plasma concentrations of Gpld1 in mice were found to increase after exercise and to correlate with improved cognitive function, and concentrations of GPLD1 in blood were increased in active elderly humans.

Interactions

GPLD1 has been shown to interact with Apolipoprotein A1 and APOA4.