GPSM1

GPSM1

Identifiers

GPSM1, AGS3, G-protein signaling modulator 1, G protein signaling modulator 1

External IDs

OMIM: 609491; MGI: 1915089; GeneCards: GPSM1

Gene location (Human)

Chr.	Chromosome 9 (human)

Band	9q34.3	Start	136,327,476 bp
Band	9q34.3	End	136,359,605 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 A3	Start	26,205,527 bp
Band	2\|2 A3	End	26,238,249 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tibia

cardiac muscle tissue of right atrium

right hemisphere of cerebellum

retinal pigment epithelium

apex of heart

myocardium of left ventricle

ganglionic eminence

cerebellar vermis

sural nerve

right auricle of heart

Top expressed in

Rostral migratory stream

neural layer of retina

saccule

barrel cortex

cerebellar cortex

olfactory bulb

atrioventricular valve

fossa

otic placode

substantia nigra

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding GTPase regulator activity GDP-dissociation inhibitor activity
Cellular component	cytoplasm cytosol Golgi apparatus endoplasmic reticulum membrane Golgi membrane endoplasmic reticulum membrane plasma membrane cell cortex protein-containing complex
Biological process	multicellular organism development cell differentiation nervous system development positive regulation of macroautophagy negative regulation of GTPase activity negative regulation of guanyl-nucleotide exchange factor activity
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


26086


67839


ENSG00000160360


ENSMUSG00000026930


Q86YR5


Q6IR34

RefSeq (mRNA)


NM_001145638 NM_001145639 NM_001200003 NM_015597

NM_001199146 NM_001199147 NM_153410 NM_001355574 NM_001355575
NM_001355576

RefSeq (protein)


NP_001139110 NP_001139111 NP_001186932 NP_056412

NP_001186075 NP_001186076 NP_700459 NP_001342503 NP_001342504
NP_001342505

Location (UCSC)

Chr 9: 136.33 – 136.36 Mb

Chr 2: 26.21 – 26.24 Mb

PubMed search

View/Edit Human

View/Edit Mouse

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160360 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026930 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. doi:10.1074/jbc.M007573200. PMID 11278352.
↑ Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. doi:10.1074/jbc.C000509200. PMID 10969064.
1 2 "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)".

Further reading

Natochin M, Lester B, Peterson YK, et al. (2001). "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin". J. Biol. Chem. 275 (52): 40981–5. doi:10.1074/jbc.M006478200. PMID 11024022.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pattingre S, De Vries L, Bauvy C, et al. (2003). "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells". J. Biol. Chem. 278 (23): 20995–1002. doi:10.1074/jbc.M300917200. PMID 12642577.
Kaushik R, Yu F, Chia W, et al. (2004). "Subcellular Localization of LGN During Mitosis: Evidence for Its Cortical Localization in Mitotic Cell Culture Systems and Its Requirement for Normal Cell Cycle Progression". Mol. Biol. Cell. 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC 181556. PMID 12925752.
Adhikari A, Sprang SR (2004). "Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1". J. Biol. Chem. 278 (51): 51825–32. doi:10.1074/jbc.M306300200. PMID 14530282.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540. S2CID 12900159.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.

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