GRIP2

GRIP2

Identifiers

GRIP2, glutamate receptor interacting protein 2

External IDs

MGI: 2681173; GeneCards: GRIP2

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1V62, 1X5R

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6\|6 D1	Start	91,738,490 bp
Band	6\|6 D1	End	91,804,231 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

body of tongue

left ventricle

gastrocnemius muscle

thoracic diaphragm

triceps brachii muscle

vastus lateralis muscle

ventral tegmental area

cardia

right ventricle

subthalamic nucleus

Top expressed in

aortic valve

ascending aorta

substantia nigra

ventral tegmental area

lumbar subsegment of spinal cord

habenula

dorsal tegmental nucleus

superior colliculus

decidua

olfactory bulb

More reference expression data


More reference expression data

Gene ontology
Molecular function	signaling receptor complex adaptor activity
Cellular component	cytoplasm cytosol plasma membrane membrane postsynaptic density dendrite postsynaptic membrane glutamatergic synapse
Biological process	Notch signaling pathway positive regulation of signal transduction artery smooth muscle contraction protein transport positive regulation of blood pressure neurotransmitter receptor transport, endosome to postsynaptic membrane vesicle-mediated transport in synapse
Sources:Amigo / QuickGO

Databases

Species

Human

Mouse


80852


243547


n/a


ENSMUSG00000030098


Q9C0E4


n/a

RefSeq (mRNA)


NM_001080423


NM_001033353 NM_001159507

RefSeq (protein)


NP_001073892


n/a

Location (UCSC)

n/a

Chr 6: 91.74 – 91.8 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Glutamate receptor-interacting protein 2 is a protein that in humans is encoded by the GRIP2 gene.

Interactions

GRIP2 has been shown to interact with liprin-alpha-1.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030098 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GRIP2 glutamate receptor interacting protein 2".
↑ Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
↑ Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.

Further reading

| citation =

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Srivastava S, Osten P, Vilim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valtschanoff JG, Weinberg RJ, Ziff EB (1998). "Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP". Neuron. 21 (3): 581–91. doi:10.1016/S0896-6273(00)80568-1. PMID 9768844. S2CID 14448034.
Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD (1999). "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands". Neuron. 21 (6): 1453–63. doi:10.1016/S0896-6273(00)80663-7. PMID 9883737. S2CID 15441813.
Brückner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R (1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron. 22 (3): 511–24. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531.
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157. S2CID 16571878.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Lin SH, Arai AC, Wang Z, Nothacker HP, Civelli O (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. doi:10.1124/mol.60.5.916. PMID 11641419.
Stegmüller J, Werner H, Nave KA, Trotter J (2003). "The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling". J. Biol. Chem. 278 (6): 3590–8. doi:10.1074/jbc.M210010200. hdl:11858/00-001M-0000-0029-2718-4. PMID 12458226.
Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.

v t e PDB gallery
1v62: Solution structure of the 3rd PDZ domain of GRIP2 1x5r: Solution structure of the fourth PDZ domain of Glutamate receptor interacting protein 2

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