GRIPAP1

GRIPAP1
Identifiers
Aliases	GRIPAP1, GRASP-1, GRIP1 associated protein 1
External IDs	OMIM: 300408; MGI: 1859616; GeneCards: GRIPAP1
Gene location (Human)
Chr.	X chromosome (human)
End	49,002,264 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,686,806 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; sural nerve; ; anterior pituitary; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; prefrontal cortex; ; granulocyte; ; hypothalamus;
	Top expressed in
	granulocyte; ; neural layer of retina; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; yolk sac; ; nucleus of stria terminalis; ; ventricular zone; ; central gray substance of midbrain;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	endosome; blood microparticle; nucleoplasm; cytosol; intracellular membrane-bounded organelle; postsynaptic recycling endosome; membrane; cell junction; axon; dendrite; early endosome membrane; cell projection; synapse; recycling endosome membrane; glutamatergic synapse; extrinsic component of postsynaptic early endosome membrane;
Biological process	neurotransmitter receptor transport, endosome to postsynaptic membrane; regulation of modification of synaptic structure; transport; protein transport; biological process; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane; regulation of recycling endosome localization within postsynapse;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56850
	54645
	ENSG00000068400
	ENSMUSG00000031153
	Q4V328
	Q8VD04
	NM_020137; NM_207672
NM_001290455; NM_207670; NM_001359289; NM_001359290; NM_001359291;
	NM_001359293
	NP_064522
NP_001277384; NP_997553; NP_001346218; NP_001346219; NP_001346220;
	NP_001346222
	Wikidata
View/Edit Human	View/Edit Mouse

GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene.

Function

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).[supplied by OMIM]

Interactions

GRIPAP1 has been shown to interact with GRIP1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000068400 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031153 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (Aug 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.
1 2 "Entrez Gene: GRIPAP1 GRIP1 associated protein 1".

Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP (2002). "Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex". J. Biol. Chem. 277 (4): 2396–405. doi:10.1074/jbc.M106312200. PMID 11704662.
Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. hdl:2262/89271. PMID 11891216.
Ye B, Sugo N, Hurn PD, Huganir RL (2002). "Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody". Neuroscience. 114 (1): 217–27. doi:10.1016/S0306-4522(02)00142-2. PMID 12207967. S2CID 39432674.
Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
Nakata A, Ito T, Nagata M, Hori S, Sekimizu K (2004). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes Cells. 9 (11): 1125–35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Stinton LM, Selak S, Fritzler MJ (2005). "Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes". Clin. Immunol. 116 (2): 108–17. doi:10.1016/j.clim.2005.03.021. PMID 15897011.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000068400 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031153 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10896157-5] 1 2 Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (Aug 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.

[entrez-6] 1 2 "Entrez Gene: GRIPAP1 GRIP1 associated protein 1".

GRIPAP1

Function

Interactions

References

Further reading