LARGE2

LARGE2
Identifiers
Aliases	LARGE2, PP5656, GYLTL1B, glycosyltransferase-like 1B, LARGE xylosyl- and glucuronyltransferase 2
External IDs	OMIM: 609709; MGI: 2443769; GeneCards: LARGE2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	45,929,096 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	92,205,214 bp
RNA expression pattern
	Top expressed in
	gonad; ; body of pancreas; ; skin of abdomen; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; minor salivary glands; ; skin of leg; ; placenta; ; anterior pituitary; ; skin of arm;
	Top expressed in
	nasolacrimal duct; ; lip; ; parotid gland; ; tail of embryo; ; genital tubercle; ; yolk sac; ; vestibular membrane of cochlear duct; ; hair follicle; ; right kidney; ; urethra;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; catalytic activity; manganese ion binding; metal ion binding; xylosyltransferase activity; glycosyltransferase activity; UDP-xylosyltransferase activity; glucuronosyltransferase activity; protein binding;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	protein glycosylation; metabolism; protein O-linked mannosylation; muscle cell cellular homeostasis; protein O-linked glycosylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	120071
	228366
	ENSG00000165905
	ENSMUSG00000040434
	Q8N3Y3
	Q5XPT3
	NM_001300721; NM_001300722; NM_152312
	NM_001166633; NM_001290773; NM_001290774; NM_001290775; NM_172670
	NP_001287650; NP_001287651; NP_689525
	NP_001160105; NP_001277702; NP_001277703; NP_001277704; NP_766258
	Wikidata
View/Edit Human	View/Edit Mouse

Xylosyl- and glucuronyltransferase LARGE2 is an enzyme that in humans is encoded by the LARGE2 gene (previously GYLTL1B). LARGE2 is a bifunctional glycosyltransferase which is able to act as either an alpha-1,3-xylosyltransferase or a beta-1,3-glucuronyltransferase.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165905 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040434 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Brockington M, Torelli S, Prandini P, Boito C, Dolatshad NF, Longman C, Brown SC, Muntoni F (Feb 2005). "Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy". Hum Mol Genet. 14 (5): 657–65. doi:10.1093/hmg/ddi062. PMID 15661757.
↑ Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE (Sep 2005). "Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies". Glycobiology. 15 (10): 912–23. doi:10.1093/glycob/cwi094. PMID 15958417.
↑ "Entrez Gene: GYLTL1B glycosyltransferase-like 1B".
↑ "Xylosyl- and glucuronyltransferase LARGE2". uniprot.org. UniProt consortium. Retrieved 2026-09-10.

Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Fujimura K, Sawaki H, Sakai T, et al. (2005). "LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE". Biochem. Biophys. Res. Commun. 329 (3): 1162–71. doi:10.1016/j.bbrc.2005.02.082. PMID 15752776.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165905 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040434 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15661757-5] Brockington M, Torelli S, Prandini P, Boito C, Dolatshad NF, Longman C, Brown SC, Muntoni F (Feb 2005). "Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy". Hum Mol Genet. 14 (5): 657–65. doi:10.1093/hmg/ddi062. PMID 15661757.

[pmid15958417-6] Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE (Sep 2005). "Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies". Glycobiology. 15 (10): 912–23. doi:10.1093/glycob/cwi094. PMID 15958417.

[entrez-7] "Entrez Gene: GYLTL1B glycosyltransferase-like 1B".

[8] "Xylosyl- and glucuronyltransferase LARGE2". uniprot.org. UniProt consortium. Retrieved 2026-09-10.

LARGE2

See also

References

Further reading