Grancalcin

GCA

Identifiers

GCA, GCL, grancalcin

External IDs

OMIM: 607030; MGI: 1918521; GeneCards: GCA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1F4O, 1F4Q, 1K94, 1K95

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q24.2	Start	162,318,840 bp
Band	2q24.2	End	162,371,595 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 C1.3	Start	62,494,629 bp
Band	2\|2 C1.3	End	62,524,453 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

monocyte

blood

bone marrow

bone marrow cell

trabecular bone

granulocyte

spleen

germinal epithelium

C1 segment

right lung

Top expressed in

granulocyte

lumbar spinal ganglion

morula

pineal gland

primary motor cortex

olfactory epithelium

seminal vesicula

sciatic nerve

ventricular zone

retinal pigment epithelium

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding protein homodimerization activity metal ion binding calcium-dependent cysteine-type endopeptidase activity protein heterodimerization activity calcium ion binding
Cellular component	plasma membrane extracellular exosome membrane extracellular region cytosol azurophil granule lumen cytoplasm
Biological process	membrane fusion proteolysis neutrophil degranulation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


25801


227960


ENSG00000115271


ENSMUSG00000026893


P28676


Q8VC88

RefSeq (mRNA)

NM_012198 NM_001330265 NM_001330266 NM_001330267 NM_001330268
NM_001330270 NM_001330271


NM_145523

RefSeq (protein)

NP_001317194 NP_001317195 NP_001317196 NP_001317197 NP_001317199
NP_001317200 NP_036330


NP_663498

Location (UCSC)

Chr 2: 162.32 – 162.37 Mb

Chr 2: 62.49 – 62.52 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Grancalcin is a protein that in humans is encoded by the GCA gene.

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

Interactions

GCA (gene) has been shown to interact with SRI.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115271 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026893 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem. 267 (5): 2928–33. doi:10.1016/S0021-9258(19)50675-5. PMID 1737748.
↑ Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286 (Pt 2): 549–54. doi:10.1042/bj2860549. PMC 1132932. PMID 1530588.
1 2 Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.
1 2 "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein".

Further reading

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jia J, Borregaard N, Lollike K, Cygler M (2002). "Structure of Ca(2+)-loaded human grancalcin". Acta Crystallogr. D. 57 (Pt 12): 1843–9. doi:10.1107/S0907444901016511. PMID 11717497.
Lollike K, Johnsen AH, Durussel I, et al. (2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner". J. Biol. Chem. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.
Jia J, Han Q, Borregaard N, et al. (2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family". J. Mol. Biol. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.
Maki M, Narayana SV, Hitomi K (1998). "A growing family of the Ca2+-binding proteins with five EF-hand motifs". Biochem. J. 328. ( Pt 2) (Pt 2): 718–20. PMC 1218977. PMID 9441591.

v t e PDB gallery
1f4o: CRYSTAL STRUCTURE OF GRANCALCIN WITH BOUND CALCIUM 1f4q: CRYSTAL STRUCTURE OF APO GRANCALCIN 1k94: Crystal structure of des(1-52)grancalcin with bound calcium 1k95: Crystal structure of des(1-52)grancalcin with bound calcium

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.