HDAC10

HDAC10
Identifiers
Aliases	HDAC10, HD10, histone deacetylase 10
External IDs	OMIM: 608544; MGI: 2158340; GeneCards: HDAC10
Enzyme activity
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,251,405 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,012,903 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right uterine tube; ; right hemisphere of cerebellum; ; anterior pituitary; ; mucosa of transverse colon; ; spleen; ; right ovary; ; canal of the cervix; ; right frontal lobe; ; left ovary;
	Top expressed in
	granulocyte; ; right kidney; ; muscle of thigh; ; esophagus; ; lip; ; proximal tubule; ; neural layer of retina; ; lacrimal gland; ; mesenteric lymph nodes; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); protein deacetylase activity; histone deacetylase binding; protein binding; enzyme binding; hydrolase activity; histone deacetylase activity; zinc ion binding; deacetylase activity; acetylputrescine deacetylase activity; acetylspermidine deacetylase activity; metal ion binding;
Cellular component	cytoplasm; histone deacetylase complex; nucleoplasm; nucleus;
Biological process	histone H3 deacetylation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; protein deacetylation; oligodendrocyte development; negative regulation of transcription, DNA-templated; histone deacetylation; chromatin organization; macroautophagy; positive regulation of mismatch repair; peptidyl-lysine deacetylation; homologous recombination; polyamine deacetylation; spermidine deacetylation; DNA repair; DNA recombination; autophagy; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	83933
	170787
	ENSG00000100429
	ENSMUSG00000062906
	Q969S8; Q08AP5
	Q6P3E7
	NM_032019; NM_001159286
	NM_199198
	NP_001152758; NP_114408
	NP_954668
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8-acetylspermidine.

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM]

Interactions

HDAC10 has been shown to interact with Histone deacetylase 2 and Nuclear receptor co-repressor 2.

Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aminoacylase ACY1 Aspartoacylase(ACY2) ACY3 Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin
3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase Dihydroorotase
3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase
3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase
3.5.5: Nitriles/ Aminohydrolases	Nitrilase
3.5.99: Other	Riboflavinase Thiaminase II

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

HDAC10

Interactions

See also