HFM1

HFM1
Identifiers
Aliases	HFM1, MER3, POF9, SEC63D1, Si-11, Si-11-6, helicase, ATP-dependent DNA helicase homolog, ATP dependent DNA helicase homolog, helicase for meiosis 1
External IDs	OMIM: 615684; MGI: 3036246; GeneCards: HFM1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	91,404,856 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	106,926,321 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; pituitary gland; ; anterior pituitary; ; right testis; ; left testis; ; ventricular zone; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; ganglionic eminence;
	Top expressed in
	spermatocyte; ; spermatid; ; testicle; ; ganglionic eminence; ; mesencephalon; ; ventricular zone; ; embryo; ; embryo; ; neural tube; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; hydrolase activity; nucleotide binding; nucleic acid binding; helicase activity;
Cellular component	nucleolus; cytoplasm;
Biological process	resolution of meiotic recombination intermediates; meiosis; RNA secondary structure unwinding;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	164045
	330149
	ENSG00000162669
	ENSMUSG00000043410
	A2PYH4; C9JQ07
	D3Z4R1
	NM_001017975
	NM_001252516; NM_177873
	NP_001017975
	NP_001239445; NP_808541
	Wikidata
View/Edit Human	View/Edit Mouse

HFM1 is a gene that in humans encodes a protein necessary for homologous recombination of chromosomes. Biallelic mutations in HFM1 cause recessive primary ovarian insufficiency.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162669 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043410 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Wang J, Zhang W, Jiang H, Wu BL (March 2014). "Mutations in HFM1 in recessive primary ovarian insufficiency". The New England Journal of Medicine. 370 (10): 972–4. doi:10.1056/NEJMc1310150. PMID 24597873.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162669 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043410 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[WangZhang2014-5] 1 2 Wang J, Zhang W, Jiang H, Wu BL (March 2014). "Mutations in HFM1 in recessive primary ovarian insufficiency". The New England Journal of Medicine. 370 (10): 972–4. doi:10.1056/NEJMc1310150. PMID 24597873.