HIST4H4

H4-16
Identifiers
Aliases	H4-16, H4/p, histone cluster 4, H4, histone cluster 4 H4, HIST4H4, H4 histone 16, H4C5, H4C4, H4C9, H4C12, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, H4C16
External IDs	OMIM: 615069; MGI: 2448432; GeneCards: H4-16
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Gene location (Human)
Chr.	Chromosome 12 (human)
End	14,771,131 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	22,225,532 bp
RNA expression pattern
	Top expressed in
	bone marrow cell; ; Achilles tendon; ; epithelium of colon; ; tonsil; ; right uterine tube; ; prostate; ; testicle; ; sural nerve; ; body of pancreas; ; stomach;
	Top expressed in
	muscle of thigh; ; granulocyte; ; blood; ; triceps brachii muscle; ; ventricular zone; ; sternocleidomastoid muscle; ; temporal muscle; ; quadriceps femoris muscle; ; soleus muscle; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein domain specific binding; protein binding; protein heterodimerization activity; DNA binding; histone binding; RNA binding;
Cellular component	membrane; chromosome; nucleoplasm; extracellular region; nuclear chromosome; nucleosome; extracellular exosome; nucleus; extracellular matrix; protein-containing complex;
Biological process	telomere organization; epigenetic maintenance of chromatin in transcription-competent conformation; protein heterotetramerization; negative regulation of megakaryocyte differentiation; CENP-A containing chromatin assembly; DNA replication-dependent chromatin assembly; rDNA heterochromatin assembly; negative regulation of gene expression, epigenetic; DNA-templated transcription, initiation; double-strand break repair via nonhomologous end joining; beta-catenin-TCF complex assembly; telomere capping; nucleosome assembly; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	121504
	319158
	ENSG00000197837
	ENSMUSG00000060639
	P62805
	P62806
	NM_175054
	NM_175656
NP_003537; NP_003486; NP_003535; NP_003539; NP_003531;
	NP_003536
NP_291074; NP_783587; NP_783588; NP_835499; NP_835500;
	NP_001182350; NP_835515; NP_783585; NP_783586; NP_835582; NP_835583; NP_783583; NP_694813
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.