HMHA1

ARHGAP45
Identifiers
Aliases	ARHGAP45, HA-1, HLA-HA1, HMHA1, histocompatibility (minor) HA-1, Rho GTPase activating protein 45
External IDs	OMIM: 601155; MGI: 1917969; GeneCards: ARHGAP45
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D25, 3FT3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,086,628 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,867,306 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; oocyte; ; secondary oocyte; ; monocyte; ; lymph node; ; thymus; ; appendix; ; bone marrow cell;
	Top expressed in
	granulocyte; ; thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; tibiofemoral joint; ; bone marrow; ; stroma of bone marrow; ; subcutaneous adipose tissue; ; ankle joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; GTPase activator activity;
Cellular component	cytosol; extracellular region; secretory granule lumen; azurophil granule lumen; cytoplasm; plasma membrane; membrane; ruffle membrane; cell projection;
Biological process	positive regulation of GTPase activity; intracellular signal transduction; regulation of small GTPase mediated signal transduction; signal transduction; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23526
	70719
	ENSG00000180448
	ENSMUSG00000035697
	Q92619
	Q3TBD2
	NM_001258328; NM_001282334; NM_001282335; NM_012292; NM_001321232
	NM_001142701; NM_027521; NM_001347074
	NP_001245257; NP_001269263; NP_001269264; NP_001308161; NP_036424
	NP_001136173; NP_001334003; NP_081797
	Wikidata
View/Edit Human	View/Edit Mouse

Minor histocompatibility protein HA-1 (or HMHA1) is a protein that in humans is encoded by the ARHGAP45 gene. More specifically, the protein encoded by ARHGAP45 is cleaved to form the histocompatibility antigen called HA-1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000180448 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035697 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312–317. doi:10.1111/j.1399-0039.1998.tb03053.x. PMID 9820596.
↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi:10.1093/dnares/3.5.321. PMID 9039502.
↑ "Entrez Gene: HMHA1 histocompatibility (minor) HA-1".
↑ "Rho GTPase-activating protein 45". uniprot.org. UniProt consortium. Retrieved 2026-09-10.

van Lochem E, van der Keur M, Mommaas AM, et al. (1997). "Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells". Transpl. Immunol. 4 (2): 151–157. doi:10.1016/S0966-3274(96)80009-8. hdl:1887/2991. PMID 8843592.
Aróstegui JI, Gallardo D, Rodríguez-Luaces M, et al. (2001). "Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)". Tissue Antigens. 56 (1): 69–76. doi:10.1034/j.1399-0039.2000.560109.x. PMID 10958358.
Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochem. Biophys. Res. Commun. 278 (3): 782–789. doi:10.1006/bbrc.2000.3880. PMID 11095984.
Gillespie G, Mutis T, Schrama E, et al. (2002). "HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand". Hematol. J. 1 (6): 403–10. doi:10.1038/sj/thj/6200065. PMID 11920221.
Fujii N, Hiraki A, Ikeda K, et al. (2002). "Expression of minor histocompatibility antigen, HA-1, in solid tumor cells". Transplantation. 73 (7): 1137–1141. doi:10.1097/00007890-200204150-00022. PMID 11965046. S2CID 21504762.
Mutis T, Blokland E, Kester M, et al. (2002). "Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation". Blood. 100 (2): 547–552. doi:10.1182/blood-2002-01-0024. PMID 12091347. S2CID 31440495.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wilke M, Dolstra H, Maas F, et al. (2004). "Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies". Hematol. J. 4 (5): 315–320. doi:10.1038/sj.thj.6200318. PMID 14502255.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C, et al. (2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation". Transplant. Proc. 36 (6): 1735–1738. doi:10.1016/j.transproceed.2004.06.007. PMID 15350465.
Mommaas B, Stegehuis-Kamp JA, van Halteren AG, et al. (2005). "Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1". Blood. 105 (4): 1823–1827. doi:10.1182/blood-2004-07-2832. PMID 15498856.
Harangi M, Kaminski WE, Fleck M, et al. (2005). "Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome". Eur. J. Immunol. 35 (1): 305–317. doi:10.1002/eji.200425406. PMID 15593299.
Krishnan NS, Higgins RM, Lam FT, et al. (2007). "HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation". Transplant. Proc. 39 (5): 1439–1445. doi:10.1016/j.transproceed.2007.02.066. PMID 17580157.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000180448 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035697 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9820596-5] Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312–317. doi:10.1111/j.1399-0039.1998.tb03053.x. PMID 9820596.

[pmid9039502-6] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi:10.1093/dnares/3.5.321. PMID 9039502.

[entrez-7] "Entrez Gene: HMHA1 histocompatibility (minor) HA-1".

[8] "Rho GTPase-activating protein 45". uniprot.org. UniProt consortium. Retrieved 2026-09-10.

HMHA1

References

Further reading