HMS Holmes has been the name of more than one ship of the British Royal Navy, and may refer to:
- HMS Holmes, a sixth rate frigate commanded by George Rooke from November 1673.
- HMS Tobago (K585), a frigate in commission from 1944 to 1945 briefly named Holmes while under construction in 1943
- HMS Holmes (K581), a frigate in commission from 1944 to 1945
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.