HNRNPLL

HNRNPLL
Identifiers
Aliases	HNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like
External IDs	OMIM: 611208; MGI: 1919942; GeneCards: HNRNPLL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WEX, 2E5I
Gene location (Human)
Chr.	Chromosome 2 (human)
End	38,603,586 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	80,369,763 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; pancreatic epithelial cell; ; cartilage tissue; ; parotid gland; ; tail of epididymis; ; left testis; ; right testis; ; saphenous vein; ; gonad;
	Top expressed in
	medial ganglionic eminence; ; primitive streak; ; abdominal wall; ; somite; ; barrel cortex; ; condyle; ; tail of embryo; ; fossa; ; superior cervical ganglion; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; mRNA binding; nucleic acid binding; RNA binding;
Cellular component	membrane; nucleus;
Biological process	positive regulation of RNA splicing; mRNA processing;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	92906
	72692
	ENSG00000143889
	ENSMUSG00000024095
	Q8WVV9
	Q921F4
	NM_001142650; NM_138394
	NM_144802
	NP_001136122; NP_612403
	NP_659051
	Wikidata
View/Edit Human	View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.

Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y (November 2011). "Proteomic dissection of the von Hippel-Lindau (VHL) interactome". Journal of Proteome Research. 10 (11): 5175–82. doi:10.1021/pr200642c. PMC 3208728. PMID 21942715.
Topp JD, Jackson J, Melton AA, Lynch KW (October 2008). "A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4". RNA. 14 (10): 2038–49. doi:10.1261/rna.1212008. PMC 2553740. PMID 18719244.
Wu Z, Yates AL, Hoyne GF, Goodnow CC (July 2010). "Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation". Journal of Immunology. 185 (1): 231–8. doi:10.4049/jimmunol.0903625. PMID 20505149.
Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA (December 2011). "Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical and Biophysical Research Communications. 416 (3–4): 258–65. doi:10.1016/j.bbrc.2011.10.126. PMID 22079093.
Shur I, Ben-Avraham D, Benayahu D (June 2004). "Alternatively spliced isoforms of a novel stromal RNA regulating factor". Gene. 334: 113–21. doi:10.1016/j.gene.2004.03.012. PMID 15256261.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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