Hippocalcin-like protein 4

HPCAL4
Identifiers
Aliases	HPCAL4, HLP4, hippocalcin like 4
External IDs	MGI: 2157521; GeneCards: HPCAL4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	39,691,485 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	123,088,494 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; anterior cingulate cortex; ; dorsolateral prefrontal cortex; ; nucleus accumbens; ; amygdala; ; Brodmann area 9;
	Top expressed in
	subiculum; ; amygdala; ; piriform cortex; ; anterior amygdaloid area; ; Region I of hippocampus proper; ; nucleus accumbens; ; prefrontal cortex; ; primary motor cortex; ; hippocampus proper; ; dentate gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; calcium channel regulator activity; protein binding; metal ion binding; protein C-terminus binding; protein domain specific binding;
Cellular component	intracellular anatomical structure;
Biological process	central nervous system development; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51440
	170638
	ENSG00000116983
	ENSMUSG00000046093
	Q9UM19
	Q8BGZ1
	NM_016257; NM_001282396; NM_001282397
	NM_174998
	NP_001269325; NP_001269326; NP_057341
	NP_778163
	Wikidata
View/Edit Human	View/Edit Mouse

Hippocalcin like 4, also known as HPCAL4, is a human gene.

Function

The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. It is a member of the neuronal calcium sensor family. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites.

Kobayashi M, Sakai E, Furuta Y, Takamatsu K (1999). "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes". DNA Sequence. 9 (3): 171–6. doi:10.3109/10425179809072192. PMID 10520747.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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