HS1BP3

HS1BP3
Identifiers
Aliases	HS1BP3, ETM2, HS1-BP3, HCLS1 binding protein 3
External IDs	OMIM: 609359; MGI: 1913224; GeneCards: HS1BP3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	20,651,130 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	8,393,824 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; ascending aorta; ; gastric mucosa; ; muscle layer of sigmoid colon; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; Descending thoracic aorta; ; monocyte;
	Top expressed in
	gastrula; ; epithelium of small intestine; ; decidua; ; lumbar spinal ganglion; ; Ileal epithelium; ; granulocyte; ; lactiferous gland; ; choroid plexus of fourth ventricle; ; yolk sac; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol binding; protein binding;
Cellular component	endoplasmic reticulum; mitochondrion;
Biological process	regulation of apoptotic process; negative regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64342
	58240
	ENSG00000118960
	ENSMUSG00000020605
	Q53T59
	Q3TC93
	NM_022460; NM_106552
	NM_021429
	NP_071905
	NP_067404
	Wikidata
View/Edit Human	View/Edit Mouse

HCLS1 binding protein 3 also known as HS1BP3 is a protein which in humans is encoded by the HS1BP3 gene.

Function

The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1-interacting protein that may be involved in lymphocyte activation.

HS1BP3 binds members of the 14-3-3 protein family, which are highly expressed in motor neurons and Purkinje cells and regulate the Ca²⁺ / calmodulin-dependent protein kinase activation of tyrosine and tryptophan hydroxylase.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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