Galectin-related protein

LGALSL
Identifiers
Aliases	LGALSL, GRP, HSPC159, galectin like
External IDs	OMIM: 617902; MGI: 1916114; GeneCards: LGALSL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JJ6, 3B9C
Gene location (Human)
Chr.	Chromosome 2 (human)
End	64,461,381 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	20,781,056 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of hip; ; gums; ; gingival epithelium; ; vulva; ; Skeletal muscle tissue of rectus abdominis; ; skin of abdomen; ; human penis; ; oral cavity; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	retinal pigment epithelium; ; hair follicle; ; skin of external ear; ; intercostal muscle; ; barrel cortex; ; skin of abdomen; ; pineal gland; ; vastus lateralis muscle; ; lobe of cerebellum; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Orthologs
Databases	NCBI: entry; OMA: entry
	29094
	216551
	ENSG00000119862
	ENSMUSG00000042363
	Q3ZCW2
	Q8VED9
	NM_014181
	NM_173752
	NP_054900
	NP_776113
	Wikidata
View/Edit Human	View/Edit Mouse

Galectin-related protein is a protein which in humans is encoded by the gene LGALSL (previously HSPC159 or GRP). It is related to other galectin proteins, but unlike others, it does not bind to lactose, and may not bind to any carbohydrates due to changes in resides that are important for carbohydrate binding.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119862 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042363 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: HSPC159 galectin-related protein".
↑ "Q3ZCW2 · LEGL_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

Ahmed H, Vasta GR (2007). "Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a functional carbohydrate-binding galectin". Biochem. Biophys. Res. Commun. 371 (3): 350–5. doi:10.1016/j.bbrc.2008.04.078. PMC 2766801. PMID 18448074.
Zhou D, Sun J, Zhao W, et al. (2006). "Expression, purification, crystallization and preliminary X-ray characterization of the GRP carbohydrate-recognition domain from Homo sapiens". Acta Crystallographica Section F. 62 (Pt 5): 474–6. doi:10.1107/S1744309106012875. PMC 2219983. PMID 16682780.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119862 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042363 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HSPC159 galectin-related protein".

[6] "Q3ZCW2 · LEGL_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

Galectin-related protein

References

Further reading