HTATIP2

HTATIP2

Identifiers

HTATIP2, CC3, SDR44U1, TIP30, HIV-1 Tat interactive protein 2

External IDs

OMIM: 605628; MGI: 1859271; GeneCards: HTATIP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2BKA

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11p15.1	Start	20,363,685 bp
Band	11p15.1	End	20,383,782 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7\|7 B4	Start	49,408,863 bp
Band	7\|7 B4	End	49,423,723 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

mucosa of colon

duodenum

mucosa of sigmoid colon

islet of Langerhans

sperm

mucosa of transverse colon

rectum

monocyte

epithelium of nasopharynx

Top expressed in

transitional epithelium of urinary bladder

stroma of bone marrow

epithelium of stomach

duodenum

lumbar spinal ganglion

left lobe of liver

pyloric antrum

mucous cell of stomach

seminal vesicula

decidua

More reference expression data


More reference expression data

Gene ontology
Molecular function	oxidoreductase activity transcription coactivator activity protein binding
Cellular component	cytoplasm nuclear envelope membrane nucleus cytosol
Biological process	multicellular organism development regulation of transcription by RNA polymerase II cell differentiation viral process negative regulation of apoptotic process regulation of angiogenesis angiogenesis import into nucleus apoptotic process positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10553


53415


ENSG00000109854


ENSMUSG00000039745


Q9BUP3


Q9Z2G9

RefSeq (mRNA)


NM_006410 NM_001098520 NM_001098521 NM_001098522 NM_001098523


NM_001146049 NM_001146050 NM_001146052 NM_001146053 NM_016865

RefSeq (protein)


NP_001091990 NP_001091991 NP_001091992 NP_001091993 NP_006401


NP_001139521 NP_001139522 NP_001139524 NP_001139525 NP_058561

Location (UCSC)

Chr 11: 20.36 – 20.38 Mb

Chr 7: 49.41 – 49.42 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Oxidoreductase HTATIP2 is an enzyme that in humans is encoded by the HTATIP2 gene. It may be a metastasis suppressor.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109854 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039745 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Xiao H, Tao Y, Greenblatt J, Roeder RG (Apr 1998). "A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription". Proc Natl Acad Sci U S A. 95 (5): 2146–51. Bibcode:1998PNAS...95.2146X. doi:10.1073/pnas.95.5.2146. PMC 19278. PMID 9482853.
↑ Shtivelman E (Jun 1997). "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma". Oncogene. 14 (18): 2167–73. doi:10.1038/sj.onc.1201059. PMID 9174052.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
↑ "Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Baker ME (1999). "TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases". Curr. Biol. 9 (13): R471. Bibcode:1999CBio....9.R471B. doi:10.1016/S0960-9822(99)80297-8. PMID 10395547. S2CID 7740085.
Whitman S, Wang X, Shalaby R, Shtivelman E (2000). "Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis". Mol. Cell. Biol. 20 (2): 583–93. doi:10.1128/MCB.20.2.583-593.2000. PMC 85138. PMID 10611237.
Xiao H, Palhan V, Yang Y, Roeder RG (2000). "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes". EMBO J. 19 (5): 956–63. doi:10.1093/emboj/19.5.956. PMC 305635. PMID 10698937.
Baker ME, Yan L, Pear MR (2000). "Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression". Cell. Mol. Life Sci. 57 (5): 851–8. doi:10.1007/s000180050047. PMC 11147082. PMID 10892349. S2CID 25141732.
NicAmhlaoibh R, Shtivelman E (2001). "Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro". Oncogene. 20 (2): 270–5. doi:10.1038/sj.onc.1204075. PMID 11313954.
Ito M, Jiang C, Krumm K, Zhang X, Pecha J, Zhao J, Guo Y, Roeder RG, Xiao H (2004). "TIP30 deficiency increases susceptibility to tumorigenesis". Cancer Res. 63 (24): 8763–7. PMID 14695192.
Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription". J. Biol. Chem. 279 (26): 27781–9. doi:10.1074/jbc.M401809200. PMID 15073177.
Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S, Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani M, Yamaoka T, Inoue H, Itakura M (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3". Mol. Cell. Biol. 24 (16): 7091–101. doi:10.1128/MCB.24.16.7091-7101.2004. PMC 479715. PMID 15282309.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Sun L, Feng S, Reséndiz JC, Lu X, Durante W, Kroll MH (2005). "Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation". Annals of Biomedical Engineering. 32 (9): 1193–201. doi:10.1114/B:ABME.0000039353.97347.28. PMID 15493507. S2CID 31410967.
Shi M, Zhang X, Wang P, Zhang HW, Zhang BH, Wu MC (2005). "TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway". World J. Gastroenterol. 11 (2): 221–7. doi:10.3748/wjg.v11.i2.221. PMC 4205406. PMID 15633220.
El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK (2005). "Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor". J. Biol. Chem. 280 (18): 18229–36. doi:10.1074/jbc.M501113200. PMID 15728189.
Caldwell RL, Lane KB, Shepherd VL (2006). "HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription". Arch. Biochem. Biophys. 449 (1–2): 27–33. doi:10.1016/j.abb.2006.02.020. PMID 16615932.

v t e PDB gallery
2bka: CC3(TIP30) crystal structure 2fmu: Crystal structure of Tat-interacting protein 30 kDa (HIV-1 tat interactive protein 2, 30 kDa homolog) (Human) (16924205) from Mus musculus at 2.30 A resolution

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