Serine protease HTRA1

HTRA1
Identifiers
Aliases	HTRA1, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, CADASIL2, HtrA serine peptidase 1
External IDs	OMIM: 602194; MGI: 1929076; GeneCards: HTRA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JOA, 2YTW, 3NUM, 3NWU, 3NZI, 3TJN, 3TJO, 3TJQ
Gene location (Human)
Chr.	Chromosome 10 (human)
End	122,514,907 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	130,587,390 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; glomerulus; ; metanephric glomerulus; ; Descending thoracic aorta; ; stromal cell of endometrium; ; ascending aorta; ; synovial membrane; ; middle frontal gyrus; ; synovial joint; ; putamen;
	Top expressed in
	decidua; ; epithelium of lens; ; facial motor nucleus; ; gastrula; ; cumulus cell; ; calvaria; ; umbilical cord; ; ascending aorta; ; motor neuron; ; tunica media of zone of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor binding; growth factor binding; peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity; protein binding; identical protein binding;
Cellular component	cytoplasm; cytosol; membrane; extracellular matrix; plasma membrane; extracellular exosome; extracellular region; extracellular space; collagen-containing extracellular matrix;
Biological process	negative regulation of defense response to virus; chorionic trophoblast cell differentiation; positive regulation of epithelial cell proliferation; placenta development; dentinogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; proteolysis; negative regulation of BMP signaling pathway; regulation of cell growth; extracellular matrix disassembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5654
	56213
	ENSG00000166033
	ENSMUSG00000006205
	Q92743
	Q9R118
	NM_002775
	NM_019564
	NP_002766
	NP_062510
	Wikidata
View/Edit Human	View/Edit Mouse

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene.

Structure

The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin-like peptidase domain and a PDZ domain.

This gene encodes a member of the trypsin family of serine proteases.

Function

This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.

Clinical significance

Mutations of this gene are responsible for the development of CARASIL, a genetic form of cerebral vasculopathy.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166033 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006205 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zumbrunn J, Trueb B (January 1997). "Primary structure of a putative serine protease specific for IGF-binding proteins". FEBS Letters. 398 (2–3): 187–192. doi:10.1016/S0014-5793(96)01229-X. PMID 8977104. S2CID 39934612.
1 2 "Entrez Gene: HTRA1 HtrA serine peptidase 1".

External links

Bradley DT, Zipfel PF, Hughes AE (June 2011). "Complement in age-related macular degeneration: a focus on function". Eye. 25 (6). London, England: 683–693. doi:10.1038/eye.2011.37. PMC 3178140. PMID 21394116.
Zurawa-Janicka D, Narkiewicz J, Lipińska B (2007). "[Characterization of the HtrA family of proteins]". Postepy Biochemii. 53 (1): 27–36. PMID 17718385.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–358. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Zumbrunn J, Trueb B (1998). "Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2". Genomics. 45 (2): 461–462. doi:10.1006/geno.1997.4953. PMID 9344681.
Hu SI, Carozza M, Klein M, Nantermet P, Luk D, Crowl RM (December 1998). "Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage". The Journal of Biological Chemistry. 273 (51): 34406–34412. doi:10.1074/jbc.273.51.34406. PMID 9852107.
Baldi A, De Luca A, Morini M, Battista T, Felsani A, Baldi F, et al. (September 2002). "The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells". Oncogene. 21 (43): 6684–6688. doi:10.1038/sj.onc.1205911. PMID 12242667. S2CID 9021435.
Nie GY, Hampton A, Li Y, Findlay JK, Salamonsen LA (April 2003). "Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2". The Biochemical Journal. 371 (Pt 1): 39–48. doi:10.1042/BJ20021569. PMC 1223265. PMID 12513693.
De Luca A, De Falco M, Severino A, Campioni M, Santini D, Baldi F, et al. (October 2003). "Distribution of the serine protease HtrA1 in normal human tissues". The Journal of Histochemistry and Cytochemistry. 51 (10): 1279–1284. doi:10.1177/002215540305101004. PMID 14500695. S2CID 19726897.
Chien J, Staub J, Hu SI, Erickson-Johnson MR, Couch FJ, Smith DI, et al. (February 2004). "A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer". Oncogene. 23 (8): 1636–1644. doi:10.1038/sj.onc.1207271. PMID 14716297.
Oka C, Tsujimoto R, Kajikawa M, Koshiba-Takeuchi K, Ina J, Yano M, et al. (March 2004). "HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins". Development. 131 (5). Cambridge, England: 1041–1053. doi:10.1242/dev.00999. PMID 14973287. S2CID 27495047.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przybylski M, et al. (April 2005). "Implications of the serine protease HtrA1 in amyloid precursor protein processing". Proceedings of the National Academy of Sciences of the United States of America. 102 (17): 6021–6026. doi:10.1073/pnas.0501823102. PMC 1087941. PMID 15855271.
Ozturk A, Desai PP, Minster RL, Dekosky ST, Kamboh MI (2005). "Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease". Neurobiology of Aging. 26 (8): 1161–1165. doi:10.1016/j.neurobiolaging.2004.11.001. PMID 15917099. S2CID 10878355.
Grau S, Richards PJ, Kerr B, Hughes C, Caterson B, Williams AS, et al. (March 2006). "The role of human HtrA1 in arthritic disease". The Journal of Biological Chemistry. 281 (10): 6124–6129. doi:10.1074/jbc.M500361200. PMID 16377621.
Bowden MA, Di Nezza-Cossens LA, Jobling T, Salamonsen LA, Nie G (October 2006). "Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer". Gynecologic Oncology. 103 (1): 253–260. doi:10.1016/j.ygyno.2006.03.006. PMID 16650464.
Chien J, Aletti G, Baldi A, Catalano V, Muretto P, Keeney GL, et al. (July 2006). "Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity". The Journal of Clinical Investigation. 116 (7): 1994–2004. doi:10.1172/JCI27698. PMC 1474818. PMID 16767218.
Dewan A, Liu M, Hartman S, Zhang SS, Liu DT, Zhao C, et al. (November 2006). "HTRA1 promoter polymorphism in wet age-related macular degeneration". Science. 314 (5801). New York, N.Y.: 989–992. doi:10.1126/science.1133807. PMID 17053108. S2CID 85725181.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166033 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006205 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Zumbrunn_1997-5] Zumbrunn J, Trueb B (January 1997). "Primary structure of a putative serine protease specific for IGF-binding proteins". FEBS Letters. 398 (2–3): 187–192. doi:10.1016/S0014-5793(96)01229-X. PMID 8977104. S2CID 39934612.

[entrez-6] 1 2 "Entrez Gene: HTRA1 HtrA serine peptidase 1".