Hazel Sive

Hazel Louise Sive
Hazel Sive in 2017
Education
Awards
  • MacVicar Faculty Fellow, MIT (2015)
  • National Science Foundation Young Investigator Award (1992)
  • Searle Scholar Award (1992)
Scientific career
Workplaces

Hazel L. Sive is a South African scientist. She currently serves as Dean of the College of Science and Mathematics at the University of Massachusetts. Sive's research includes studies of neurological and neurodevelopmental disorders, such as epilepsy, autism, and 16p11.2 deletion syndrome.

Education

Sive received her Bachelor of Science with honors in 1979 from the University of the Witwatersrand in Johannesburg, South Africa with a double major in zoology and chemistry.[dead link][citation needed]

Research

Sive's research includes analysis of the extreme anterior domain (EAD), a region found in developing embryos that develops into the mouth opening and oral cavity. This research defined key steps of mouth formation and determined that the EAD is a facial signaling center that guides neural crest cells into the developing face, where they form the jaws and other structures.

Sive has conducted research into nervous system patterning.[citation needed] She was involved in the development of subtractive cloning techniques used to define nervous system molecular markers and regulators in Xenopus frogs and the zebrafish Danio. Expression of these genes determine the point at which an embryo begins to develop a nervous system: Sive determined that future brain cells are set aside when the embryo is just a ball of cells.[citation needed] Sive was the first to use hormone-inducible fusion proteins to study these genes.

Sive developed the first zebrafish 'explant' culture method, and identified cell interactions that initiate brain development. Sive identified retinoic acid as a regulator of brain patterning, and demonstrated its activity on expression of hindbrain Hox genes. She defined additional roles for fibroblast growth factors in precise patterning of the hindbrain.

Sive was instrumental in the identification of "basal constriction" as a cell-shape-change occurring during brain morphogenesis. They identified the process of "epithelial relaxation," a cell-sheet-stretching process that occurs as brain ventricles form. She was one of the first to use zebrafish to study the brain ventricular system: cavities filled with cerebrospinal fluid (CSF) that form the body's "third circulation." This research identified Retinol Binding Protein in the CSF as essential for the survival of brain cells.

Sive investigated zebrafish as a tool for probing gene function associated with autism spectrum disorders. Her group has identified genes that interact and contribute to brain dysfunction in the prevalent and serious 16p11.2 deletion syndrome, implicating lipid metabolism in symptomatology.

Sive is the editor of Xenopus: A Laboratory Manual.

Academic roles and awards

In 2015, she was named a MacVicar Faculty Fellow, MIT's highest award for undergraduate teaching[failed verification].

She received the MIT School of Science Teaching Award (2003), MIT's Alan J. Lazarus Advising Award in 2016, and the MIS School of Science Teaching Award for Undergraduate Education in 2019.[dead link] Several of her courses are offered through the MIT OpenCourseWare online initiative.[dead link][citation needed]

Sive was chair of the MIT Biology Undergraduate Program (2003–2006) and served as the first Associate Dean for the MIT School of Science (2006–2013).

Sive has served as chair of the MIT Committee on Student Life and as founding chair of the MIT Faculty Postdoctoral Advisory Committee.[dead link][citation needed]

In 2014, Sive founded and is Director of the MIT-Africa initiative, leading the Africa Advisory Committee to write a Strategic Plan for MIT Engagement in Africa.[dead link][citation needed]

In 2017, Sive was named Director of Higher Education at the MIT Jameel World Education Lab (J-WEL).[dead link][citation needed]

She was formerly a Member of the Whitehead Institute and joined the MIT faculty in 1991.

In November 2021, she was elected as an AAAS Fellow. Sive received the recognition for fundamental discoveries advancing our understanding of early embryonic development, particularly the development of the nervous system in vertebrates, and for her leadership in teaching, mentoring, and diversity in higher education.

In 2022, Sive was awarded an honorary doctorate in engineering from her alma mater, the University of the Witwatersrand.

References

  1. ↑ Boston, UMass. "Dean's Office - UMass Boston". www.umb.edu. Retrieved 8 January 2026.
  2. ↑ "Research | Sive Lab". sivelab.wi.mit.edu. Retrieved 7 September 2018.
  3. ↑ OpenCourseWare, MIT. "Hazel Sive | MIT OpenCourseWare | Free Online Course Materials". ocw.mit.edu. Retrieved 26 November 2017.
  4. ↑ Jacox, Laura A.; Dickinson, Amanda J.; Sive, Hazel (26 March 2014). "Facial Transplants in Xenopus laevis Embryos". Journal of Visualized Experiments (85). doi:10.3791/50697. PMC 4089428. PMID 24748020.
  5. ↑ Jacox, Laura; Chen, Justin; Rothman, Alyssa; Lathrop-Marshall, Hillary; Sive, Hazel (August 2016). "Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling". Cell Reports. 16 (5): 1445–1455. doi:10.1016/j.celrep.2016.06.073. PMC 4972695. PMID 27425611.
  6. ↑ Kolm, Peggy J.; Sive, Hazel L. (September 1995). "Efficient Hormone-Inducible Protein Function in Xenopus laevis". Developmental Biology. 171 (1): 267–272. doi:10.1006/dbio.1995.1279. PMID 7556904.
  7. ↑ Sagerström, C. G.; Grinblat, Y.; Sive, H. (June 1996). "Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions". Development. 122 (6): 1873–1883. doi:10.1242/dev.122.6.1873. ISSN 0950-1991. PMID 8674426.
  8. ↑ Kolm, Peggy J.; Sive, Hazel L. (January 1995). "Regulation of the Xenopus labial Homeodomain Genes, HoxA1 and HoxD1: Activation by Retinoids and Peptide Growth Factors". Developmental Biology. 167 (1): 34–49. doi:10.1006/dbio.1995.1005. PMID 7851655.
  9. ↑ Kolm, Peggy J.; Apekin, Vladimir; Sive, Hazel (December 1997). "XenopusHindbrain Patterning Requires Retinoid Signaling". Developmental Biology. 192 (1): 1–16. doi:10.1006/dbio.1997.8754. PMID 9405093.
  10. ↑ Gutzman, Jennifer H.; Graeden, Ellie G.; Lowery, Laura Anne; Holley, Heidi S.; Sive, Hazel (November 2008). "Formation of the zebrafish midbrain–hindbrain boundary constriction requires laminin-dependent basal constriction". Mechanisms of Development. 125 (11–12): 974–983. doi:10.1016/j.mod.2008.07.004. PMC 2780020. PMID 18682291.
  11. ↑ Gutzman, J. H.; Sive, H. (10 February 2010). "Epithelial relaxation mediated by the myosin phosphatase regulator Mypt1 is required for brain ventricle lumen expansion and hindbrain morphogenesis". Development. 137 (5): 795–804. doi:10.1242/dev.042705. PMC 2827689. PMID 20147380.
  12. ↑ Lowery, L. A. (23 March 2005). "Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a.1 gene products". Development. 132 (9): 2057–2067. doi:10.1242/dev.01791. PMID 15788456.
  13. ↑ Chang, Jessica T.; Lehtinen, Maria K.; Sive, Hazel (January 2016). "Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway". Developmental Neurobiology. 76 (1): 75–92. doi:10.1002/dneu.22300. PMC 4644717. PMID 25980532.
  14. ↑ Tropepe, V; Sive, HL (October 2003). "Can zebrafish be used as a model to study the neurodevelopmental causes of autism?". Genes, Brain and Behavior. 2 (5): 268–81. doi:10.1034/j.1601-183X.2003.00038.x. PMID 14606692.
  15. ↑ Blaker-Lee, A.; Gupta, S.; McCammon, J. M.; De Rienzo, G.; Sive, H. (1 May 2012). "Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes". Disease Models & Mechanisms. 5 (6): 834–851. doi:10.1242/dmm.009944. PMC 3484866. PMID 22566537.
  16. ↑ McCammon, Jasmine M.; Blaker-Lee, Alicia; Chen, Xiao; Sive, Hazel (1 October 2017). "The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes". Human Molecular Genetics. 26 (19): 3699–3712. doi:10.1093/hmg/ddx255. PMC 5886277. PMID 28934389.
  17. ↑ Tomasello, Danielle L.; Kim, Jiyoon L.; Khodour, Yara; McCammon, Jasmine M.; Mitalipova, Maya; Jaenisch, Rudolf; Futerman, Anthony H.; Sive, Hazel (21 January 2022). "16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis". iScience. 25 (1) 103551. doi:10.1016/j.isci.2021.103551. ISSN 2589-0042. PMC 8693007. PMID 34984324.
  18. ↑ Sive, Hazel L., ed. (2023). Xenopus: a laboratory manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. ISBN 978-1-62182-180-9.
  19. ↑ "Current MacVicar Fellows". MIT Registrar's Office.
  20. ↑ "Teaching prize recipients". MIT School of Science. Archived from the original on 30 July 2019. Retrieved 21 February 2019.
  21. ↑ "Office of Undergraduate Advising & Academic Programming | Awards Convocation". awards.mit.edu.
  22. ↑ "Mehrdad Jazayeri and Hazel Sive awarded 2019 School of Science teaching prizes". 18 September 2019.
  23. ↑ "Hazel Sive | MIT OpenCourseWare | Free Online Course Materials". ocw.mit.edu.
  24. ↑ "Hazel Sive steps down as associate dean of the School of Science". MIT News. 20 December 2013.
  25. 1 2 "Professor Hazel Sive". MIT J-WEL. 2 March 2018.
  26. ↑ "What is MIT-Africa?". MIT Africa.
  27. ↑ "Alumni, Whitehead Institute: Hazel L. Sive". wi.mit.edu.
  28. ↑ "OCW Faculty Profile: Hazel Sive". ocw.mit.edu.
  29. ↑ "2021 AAAS Fellows".
  30. ↑ "Three Northeastern Leaders Receive Lifetime Honor for Prolific Scientific Contribution". 27 January 2022.
  31. ↑ Lloyd, Noah (12 December 2022). "The door doesn't close on learning: Dean Hazel Sive receives honorary doctorate". Northeastern Global News. Retrieved 15 August 2023.