IFIT3

IFIT3
Identifiers
Aliases	IFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon induced protein with tetratricopeptide repeats 3
External IDs	OMIM: 604650; MGI: 1101055; GeneCards: IFIT3
Gene location (Human)
Chr.	Chromosome 10 (human)
End	89,377,473 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,566,131 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; jejunal mucosa; ; pericardium; ; lower lobe of lung; ; spinal ganglia; ; human penis; ; palpebral conjunctiva; ; monocyte; ; endothelial cell; ; synovial joint;
	Top expressed in
	right kidney; ; granulocyte; ; human kidney; ; thymus; ; jejunum; ; lung; ; colon; ; adrenal gland; ; spleen; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; protein binding; molecular function; RNA binding;
Cellular component	cytoplasm; mitochondrion; cytosol;
Biological process	immune system process; response to virus; innate immune response; negative regulation of apoptotic process; defense response to virus; type I interferon signaling pathway; negative regulation of cell population proliferation; cellular response to interferon-alpha; response to bacterium; cellular response to interferon-beta;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	3437
	15959
	ENSG00000119917
	ENSMUSG00000074896
	O14879
	Q64345
	NM_001549; NM_001031683; NM_001289758; NM_001289759
	NM_010501
	NP_001026853; NP_001276687; NP_001276688; NP_001540
	NP_034631
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 (ISG49), is a protein that in humans is encoded by the IFIT3 gene. It plays a part in the innate immune response to viruses in response to type I interferon signaling.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119917 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074896 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, et al. (2012). "Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis". PLOS Pathogens. 8 (5) e1002712. doi:10.1371/journal.ppat.1002712. PMC 3355090. PMID 22615570.
↑ de Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ (December 1998). "IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes". Genomics. 54 (2): 267–277. doi:10.1006/geno.1998.5555. PMID 9828129.
↑ Zhu H, Cong JP, Shenk T (December 1997). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs". Proceedings of the National Academy of Sciences of the United States of America. 94 (25): 13985–13990. Bibcode:1997PNAS...9413985Z. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.
↑ "Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3".

Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, et al. (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–221. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–197. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Yu M, Tong JH, Mao M, Kan LX, Liu MM, Sun YW, et al. (July 1997). "Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7406–7411. Bibcode:1997PNAS...94.7406Y. doi:10.1073/pnas.94.14.7406. PMC 23834. PMID 9207104.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119917 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074896 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Fensterl2012-5] 1 2 3 Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, et al. (2012). "Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis". PLOS Pathogens. 8 (5) e1002712. doi:10.1371/journal.ppat.1002712. PMC 3355090. PMID 22615570.

[pmid9828129-6] Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ (December 1998). "IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes". Genomics. 54 (2): 267–277. doi:10.1006/geno.1998.5555. PMID 9828129.

[pmid9391139-7] Zhu H, Cong JP, Shenk T (December 1997). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs". Proceedings of the National Academy of Sciences of the United States of America. 94 (25): 13985–13990. Bibcode:1997PNAS...9413985Z. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.

[entrez-8] "Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3".

IFIT3

References

Further reading