ING3

ING3
Identifiers
Aliases	ING3, Eaf4, ING2, MEAF4, p47inhibitor of growth family member 3
External IDs	OMIM: 607493; MGI: 1919027; GeneCards: ING3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X4I
Gene location (Human)
Chr.	Chromosome 7 (human)
End	120,977,216 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	21,976,037 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; trabecular bone; ; monocyte; ; testicle; ; Achilles tendon; ; bone marrow; ; tail of epididymis; ; gonad; ; germinal epithelium; ; parietal pleura;
	Top expressed in
	zygote; ; secondary oocyte; ; genital tubercle; ; tail of embryo; ; spermatid; ; granulocyte; ; primary oocyte; ; Rostral migratory stream; ; medial ganglionic eminence; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone acetyltransferase activity; methylated histone binding; metal ion binding;
Cellular component	Piccolo NuA4 histone acetyltransferase complex; nucleus; nucleoplasm; Swr1 complex; NuA4 histone acetyltransferase complex;
Biological process	histone H4 acetylation; histone H2A acetylation; regulation of growth; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of apoptotic process; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54556
	71777
	ENSG00000071243
	ENSMUSG00000029670
	Q9NXR8
	Q8VEK6
	NM_198267; NM_019071; NM_198266
	NM_023626; NM_001311061
	NP_061944; NP_938008
	NP_001297990; NP_076115
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.

Gene

Two alternatively spliced transcript variants encoding different isoforms have been observed.

Function

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21 (waf1) and bax.

Clinical significance

Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000071243 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029670 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, et al. (June 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–4470. doi:10.1038/sj.onc.1205540. PMID 12080476.
1 2 3 4 "Entrez Gene: ING3 inhibitor of growth family, member 3".

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Current Opinion in Genetics & Development. 14 (2): 147–154. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
The Sanger Centre, Washington University Genome Sequencing Centre (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Nagashima M, Shiseki M, Pedeux RM, Okamura S, Kitahama-Shiseki M, Miura K, et al. (January 2003). "A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis". Oncogene. 22 (3): 343–350. doi:10.1038/sj.onc.1206115. PMID 12545155.
Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, et al. (October 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". The Journal of Biological Chemistry. 278 (44): 42733–42736. doi:10.1074/jbc.C300389200. PMID 12963728.
Doyon Y, Selleck W, Lane WS, Tan S, Côté J (March 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Molecular and Cellular Biology. 24 (5): 1884–1896. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
Cai Y, Jin J, Florens L, Swanson SK, Kusch T, Li B, et al. (April 2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". The Journal of Biological Chemistry. 280 (14): 13665–13670. doi:10.1074/jbc.M500001200. PMID 15647280.
Wang Y, Dai DL, Martinka M, Li G (2007). "Prognostic significance of nuclear ING3 expression in human cutaneous melanoma". Clinical Cancer Research. 13 (14): 4111–4116. doi:10.1158/1078-0432.CCR-07-0408. PMID 17634537.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000071243 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029670 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Gunduz_2002-5] Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, et al. (June 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–4470. doi:10.1038/sj.onc.1205540. PMID 12080476.

[entrez-6] 1 2 3 4 "Entrez Gene: ING3 inhibitor of growth family, member 3".

ING3

Gene

Function

Clinical significance

References

Further reading