IPO4

IPO4

Identifiers

IPO4, Imp4, importin 4

External IDs

MGI: 1923001; GeneCards: IPO4

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14 C3\|14 28.19 cM	Start	55,862,857 bp
Band	14 C3\|14 28.19 cM	End	55,873,414 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

body of pancreas

gastrocnemius muscle

right uterine tube

right adrenal gland

sural nerve

anterior pituitary

left adrenal gland

kidney

skeletal muscle tissue

bone marrow cell

Top expressed in

internal carotid artery

external carotid artery

seminiferous tubule

fossa

Gonadal ridge

condyle

vas deferens

morula

arcuate nucleus

paraventricular nucleus of hypothalamus

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding nuclear localization sequence binding
Cellular component	cytoplasm nuclear membrane nuclear pore membrane nuclear periphery nucleus protein-containing complex
Biological process	protein transport DNA replication-dependent chromatin assembly intracellular protein transport ribosomal protein import into nucleus NLS-bearing protein import into nucleus transport protein import into nucleus
Sources:Amigo / QuickGO

Databases

Species

Human

Mouse


79711


75751


n/a


ENSMUSG00000002319


Q8TEX9


Q8VI75

RefSeq (mRNA)


NM_024658


NM_024267 NM_001360078

RefSeq (protein)


NP_078934


NP_077229 NP_001347007

Location (UCSC)

n/a

Chr 14: 55.86 – 55.87 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Importin-4 is a protein that in humans is encoded by the IPO4 gene.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002319 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jakel S, Mingot JM, Schwarzmaier P, Hartmann E, Gorlich D (Feb 2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
↑ "Entrez Gene: IPO4 importin 4".

Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Miyauchi Y, Michigami T, Sakaguchi N, et al. (2006). "Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor". J. Biol. Chem. 280 (49): 40901–8. doi:10.1074/jbc.M509347200. PMID 16207705.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lischka P, Sorg G, Kann M, et al. (2003). "A Nonconventional Nuclear Localization Signal within the UL84 Protein of Human Cytomegalovirus Mediates Nuclear Import via the Importin α/β Pathway". J. Virol. 77 (6): 3734–48. doi:10.1128/JVI.77.6.3734-3748.2003. PMC 149505. PMID 12610148.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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