IRS4

IRS4
Identifiers
Aliases	IRS4, IRS-4, PY160, insulin receptor substrate 4, CHNG9
External IDs	OMIM: 300904; MGI: 1338009; GeneCards: IRS4
Gene location (Human)
Chr.	X chromosome (human)
End	108,736,563 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	140,508,259 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; ovary; ; left ovary; ; right ovary; ; gastric mucosa; ; hypothalamus; ; body of uterus; ; right lobe of thyroid gland; ; cervix;
	Top expressed in
	median eminence; ; arcuate nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; substantia nigra; ; gastrula; ; mammillary body; ; lateral hypothalamus; ; nucleus of stria terminalis; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol 3-kinase binding; protein binding; signal transducer activity; insulin receptor binding;
Cellular component	cytosol; membrane; plasma membrane;
Biological process	insulin receptor signaling pathway; regulation of lipid metabolic process; signal transduction; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8471
	16370
	ENSG00000133124
	ENSMUSG00000054667
	O14654
	Q9Z0Y7
	NM_003604; NM_001379150
	NM_010572
	NP_003595; NP_001366079
	NP_034702
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.

Interactions

IRS4 has been shown to interact with CRK and NISCH.