ITIH4

ITIH4

Identifiers

ITIH4, GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120, inter-alpha-trypsin inhibitor heavy chain family member 4, inter-alpha-trypsin inhibitor heavy chain 4

External IDs

OMIM: 600564; MGI: 109536; GeneCards: ITIH4

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3p21.1	Start	52,812,962 bp
Band	3p21.1	End	52,830,688 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14 B\|14 19.09 cM	Start	30,608,433 bp
Band	14 B\|14 19.09 cM	End	30,624,310 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

right coronary artery

popliteal artery

tibial arteries

left coronary artery

body of pancreas

muscle of thigh

sperm

right adrenal cortex

gastrocnemius muscle

Top expressed in

left lobe of liver

ascending aorta

aortic valve

gallbladder

tunica media of zone of aorta

right lung lobe

carotid body

sexually immature organism

fetal liver hematopoietic progenitor cell

embryo

More reference expression data

n/a

Gene ontology
Molecular function	peptidase inhibitor activity endopeptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity
Cellular component	cytoplasm plasma membrane blood microparticle extracellular exosome platelet dense granule lumen extracellular region collagen-containing extracellular matrix
Biological process	response to cytokine negative regulation of peptidase activity acute-phase response hyaluronan metabolic process platelet degranulation negative regulation of endopeptidase activity
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


3700


16427


ENSG00000055955


ENSMUSG00000021922


Q14624


A6X935

RefSeq (mRNA)


NM_002218 NM_001166449


NM_001159299 NM_001289632 NM_001289633 NM_018746

RefSeq (protein)


NP_001159921 NP_002209


NP_001152771 NP_001276561 NP_001276562 NP_061216

Location (UCSC)

Chr 3: 52.81 – 52.83 Mb

Chr 14: 30.61 – 30.62 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ITIH4 gene.

See also

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000055955 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021922 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP (Mar 1998). "The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human". Biochem Biophys Res Commun. 243 (2): 522–30. doi:10.1006/bbrc.1998.8128. PMID 9480842.
↑ Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S (Feb 1995). "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein". FEBS Lett. 357 (2): 207–11. Bibcode:1995FEBSL.357..207H. doi:10.1016/0014-5793(94)01364-7. PMID 7805892.
↑ "Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)".

Further reading

Choi-Miura NH, Sano Y, Oda E, et al. (1995). "Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma". J. Biochem. 117 (2): 400–7. doi:10.1093/jb/117.2.400. PMID 7541790.
Tobe T, Saguchi K, Hashimoto K, et al. (1995). "Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21→p14". Cytogenet. Cell Genet. 71 (3): 296–8. doi:10.1159/000134130. PMID 7587397.
Saguchi K, Tobe T, Hashimoto K, et al. (1995). "Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein". J. Biochem. 117 (1): 14–8. doi:10.1093/oxfordjournals.jbchem.a124701. PMID 7775381.
Saguchi K, Tobe T, Hashimoto K, et al. (1997). "Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)". J. Biochem. 119 (5): 898–905. doi:10.1093/oxfordjournals.jbchem.a021327. PMID 8797089.
Jean L, Smih F, Olivier E, et al. (1997). "Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14". Genomics. 41 (1): 139–40. doi:10.1006/geno.1997.4612. PMID 9126497.
Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi:10.1074/jbc.273.41.26809. PMID 9756925.
Tozaki T, Choi-Miura NH, Taniyama M, et al. (2003). "SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method". BMC Med. Genet. 3: 6. doi:10.1186/1471-2350-3-6. PMC 117798. PMID 12147176.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
Fujita Y, Ezura Y, Emi M, et al. (2004). "Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene". J. Hum. Genet. 49 (1): 24–8. doi:10.1007/s10038-003-0101-8. PMID 14661079.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718. S2CID 29261009.
Kroczynska B, King-Simmons L, Alloza L, et al. (2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4". Biochem. Biophys. Res. Commun. 338 (3): 1467–77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

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