Immunoconjugate

Immunoconjugates are antibodies conjugated (joined) to a second molecule, usually a toxin, radioisotope or label.

These conjugates are used in immunotherapy[citation needed] and to develop monoclonal antibody therapy as a targeted form of chemotherapy when they are often known as antibody-drug conjugates.

Immunoconjugates that include a radioisotope are used in radioimmunotherapy. When immunoconjugates include a toxin, they are known as immunotoxins.

References

  1. ↑ Goldenberg DM, Sharkey RM (2007). "Novel radiolabeled antibody conjugates". Oncogene. 26 (25): 3734–44. doi:10.1038/sj.onc.1210373. PMID 17530026.
  2. ↑ Khandare JJ, Minko T (2006). "Antibodies and peptides in cancer therapy". Critical Reviews in Therapeutic Drug Carrier Systems. 23 (5): 401–35. doi:10.1615/CritRevTherDrugCarrierSyst.v23.i5.20. PMID 17425513.

Further reading