Arylalkylamine

Substituted arylalkylamines, also alternatively known in many cases as substituted arylethylamines, are a group of chemical compounds. These compounds are divided into two main categories: indolylalkylamines and phenylalkylamines.

These compounds are related to monoamine neurotransmitters, which are chemicals in the brain that transmit signals between nerve cells. Because of this, substituted arylalkylamines can have a wide range of effects on the body and mind. They are used in many medications, including:

Many arylalkylamines act as monoamine releasing agents, monoamine reuptake inhibitors, and/or monoamine receptor modulators.

Many more foundational arylalkylamines besides the above also exist. In addition, other alkylamines and non-aromatic cyclized alkylamines exist.

See also

References

  1. ↑ Freeman S, Alder JF (July 2002). "Arylethylamine psychotropic recreational drugs: a chemical perspective". Eur J Med Chem. 37 (7): 527–539. doi:10.1016/s0223-5234(02)01382-x. PMID 12126772.
  2. 1 2 3 4 Glennon RA (October 1999). "Arylalkylamine drugs of abuse: an overview of drug discrimination studies". Pharmacol. Biochem. Behav. 64 (2): 251–256. doi:10.1016/S0091-3057(99)00045-3. PMID 10515299. S2CID 10221368.
  3. ↑ Richard K. Ries; Shannon C. Miller; David A. Fiellin (2009). Principles of Addiction Medicine. Lippincott Williams & Wilkins. pp. 245–. ISBN 978-0-7817-7477-2.
  4. ↑ Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 639–. ISBN 978-1-60913-345-0.
  5. 1 2 3 4 Trachsel D, Lehmann D, Enzensperger C (2013). "[Kapitel 4:] Heteroarylalkylamine" [[Chapter 4:] Heteroarylalkylamines]. Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German). Solothurn: Nachtschatten-Verlag. pp. 289–346. ISBN 978-3-03788-700-4. OCLC 858805226. Retrieved 29 January 2025.
  6. ↑ Trachsel D, Lehmann D, Enzensperger C (2013). "[Kapitel 5:] Ersatz des Arylteils durch nichtaromatische Reste" [[Chapter 5:] Replacement of the Aryl Moiety by Non-Aromatic Residues]. Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German). Solothurn: Nachtschatten-Verlag. pp. 289–346. ISBN 978-3-03788-700-4. OCLC 858805226. Retrieved 29 January 2025.