Integrin subunit beta like 1

ITGBL1
Identifiers
Aliases	ITGBL1, OSCP, TIED, integrin subunit beta like 1
External IDs	OMIM: 604234; MGI: 2443439; GeneCards: ITGBL1
Gene location (Human)
Chr.	Chromosome 13 (human)
End	101,720,856 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	124,213,030 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; paraflocculus of cerebellum; ; middle frontal gyrus; ; Descending thoracic aorta; ; ascending aorta; ; Achilles tendon; ; pericardium; ; synovial joint; ; right coronary artery; ; popliteal artery;
	Top expressed in
	calvaria; ; tunica media of zone of aorta; ; sciatic nerve; ; ascending aorta; ; aortic valve; ; interventricular septum; ; utricle; ; stroma of bone marrow; ; vestibular sensory epithelium; ; skin of external ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	integrin binding;
Cellular component	extracellular region; plasma membrane; focal adhesion; integrin complex; cell surface;
Biological process	cell adhesion; cell-matrix adhesion; integrin-mediated signaling pathway; cell migration; cell adhesion mediated by integrin;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9358
	223272
	ENSG00000198542
	ENSMUSG00000032925
	O95965
	Q8VDV0
	NM_001271754; NM_001271755; NM_001271756; NM_004791
	NM_145467
	NP_001258683; NP_001258684; NP_001258685; NP_004782
	NP_663442
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene.

Function

This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198542 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032925 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Integrin subunit beta like 1". Retrieved 2018-07-18.

Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
Li XQ, Du X, Li DM, Kong PZ, Sun Y, Liu PF, Wang QS, Feng YM (August 2015). "ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway". Cancer Res. 75 (16): 3302–13. doi:10.1158/0008-5472.CAN-15-0240. PMID 26060017.
Gan X, Liu Z, Tong B, Zhou J (February 2016). "Epigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling". Tumour Biol. 37 (2): 1663–9. doi:10.1007/s13277-015-3919-8. PMID 26307393. S2CID 54485581.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198542 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032925 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Integrin subunit beta like 1". Retrieved 2018-07-18.

Integrin subunit beta like 1

Function

References

Further reading