Isadore Elliot Handler (1916–2011), American inventor, business magnate, co-founder of Mattel and co-inventor, with his wife Ruth, of Barbie, Chatty Cathy and Hot Wheels
Ezomo Izzy Iriekpen (born 1982), English former footballer
Jason Isringhausen (born 1972), American former Major League Baseball pitcher and coach
Israel Izzy Katzman (1917–2007), American sportswriter
Israel Izzy Lang (born 1942), American former National Football League running back
Isidoro Izzy León (1911–2002), Major League Baseball pitcher from Cuba
Israel George Levene (1885–1930), American collegiate football player and head coach
Israel Izzy Martinez (born 1982), American wrestling coach
Isadore Schwartz (1900–1988), American boxer, world flyweight champion from 1927 to 1929
Isadore Sparber (1906–1958), American storyboard artist, writer, director and producer of animated films
Isidor I. F. Stone (1907–1989), American investigative journalist, also the "Izzy Awards," a journalism prize named for him bestowed by Roy H. Park School of Communications at Ithaca College
Isabelle Izzy Westbury (born 1990), English cricketer
Julius Izzy Yablok (1907–1983), American football player
Israel Izzy Young (1928-2019), American folk music store owner
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