Jesse Roth

Jesse Roth
Born(1934-08-05)August 5, 1934
New York, New York, U.S.
DiedMarch 11, 2026(2026-03-11) (aged 91)
Hurley, New York, U.S.
EducationColumbia University
Albert Einstein College of Medicine
Known forCell surface receptors
Scientific career
FieldsMedicine and Endocrinology
Workplaces

Jesse Roth (August 5, 1934 – March 11, 2026) was an American physician and endocrinologist at The Feinstein Institutes for Medical Research, known for his work on receptors and their role in disorders such as diabetes and obesity.

Early life and education

Roth was born in Brooklyn on August 5, 1934. He received a BA in art history in 1955 from Columbia University, and an MD in 1959 from Albert Einstein College of Medicine.

Career

Roth completed a residency in internal medicine at Barnes-Jewish Hospital (Washington University School of Medicine, St. Louis) in 1961, and a fellowship in endocrinology at Bronx Veterans Administration Medical Center in 1963. Beginning with his fellowship work with Solomon Berson and Rosalyn Yalow, Jesse Roth's research career focused on insulin action. He pioneered the concept of cell surface receptors. His laboratory at the National Institutes of Health, where he worked from 1963 to 1991, elucidated much of what we know of the structure of the insulin receptor and intracellular mechanisms of insulin action. In 1991, he took a position at Johns Hopkins University, and in 2000, he joined the Feinstein Institutes for Medical Research, where he continued to study hormones and their receptors across multiple conditions, including obesity, into his eighties.

Death

Roth died at his home in Hurley, New York, on March 11, 2026, at the age of 91.

Honors and awards

Roth was a Fellow of the American College of Physicians (FACP). He was a recipient of the 1980 Gairdner Foundation International Award and in 1982, he received the American Diabetes Association's Banting Medal for Scientific Achievement. In 2014, he received an honorary doctorate from the Weizmann Institute of Science.

References

  1. 1 2 3 Ricks, Delthia (March 27, 2026). "Jesse Roth, Who Advanced the Understanding of Diabetes, Dies at 91". The New York Times. Retrieved March 27, 2026.
  2. 1 2 3 "Jesse Roth, MD, FACP". Feinstein Institutes for Medical Research. Archived from the original on April 3, 2025.
  3. 1 2 "Jesse Roth". Weizmann Institute of Science. Retrieved March 27, 2026.
  4. ↑ Freychet, Pierre; Roth, Jesse; Neville, David M. (1971). "Insulin Receptors in the Liver: Specific Binding of [ 125 I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity". Proceedings of the National Academy of Sciences. 68 (8): 1833–1837. doi:10.1073/pnas.68.8.1833. ISSN 0027-8424. PMC 389303. PMID 4331561.
  5. ↑ Jesse Roth Dignity Memorial
  6. ↑ "Jesse Roth - Gairdner Foundation Award Winner". The Gairdner Foundation. Retrieved March 27, 2026.
  7. ↑ "Banting Medal for Scientific Achievement Award". American Diabetes Association. Archived from the original on January 22, 2015.
  8. ↑ "Honorary PhD". Weizmann Institute of Science. Retrieved March 27, 2026.