KANK2

KANK2
Identifiers
Aliases	KANK2, ANKRD25, MXRA3, SIP, PPKWH, KN motif and ankyrin repeat domains 2, NPHS16
External IDs	OMIM: 614610; MGI: 2384568; GeneCards: KANK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HBD
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,197,791 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,710,040 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; gastric mucosa; ; urethra; ; body of uterus; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; canal of the cervix; ; sural nerve; ; left uterine tube;
	Top expressed in
	ascending aorta; ; interventricular septum; ; aortic valve; ; umbilical cord; ; ciliary body; ; sciatic nerve; ; left lung lobe; ; gastrula; ; iris; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; mitochondrion;
Biological process	negative regulation of G1/S transition of mitotic cell cycle; negative regulation of programmed cell death; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of vitamin D receptor signaling pathway; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of cell population proliferation; apoptotic process; kidney epithelium development; glomerular visceral epithelial cell migration; regulation of Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	25959
	235041
	ENSG00000197256
	ENSMUSG00000032194
	Q63ZY3
	Q8BX02
	NM_015493; NM_001136191; NM_001329451
	NM_145611
NP_001129663; NP_001316380; NP_056308; NP_001366477; NP_001366478;
	NP_001366479; NP_001366480; NP_001366481; NP_001366482; NP_001366483; NP_001366484; NP_001366485; NP_001366486; NP_001366487; NP_001366488; NP_001366489; NP_001366490; NP_001366491; NP_001366492
	NP_663586
	Wikidata
View/Edit Human	View/Edit Mouse

KN motif and ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the KANK2 gene (previously ANKRD25). KANK2 has various regulatory functions, including regulating nuclear receptor coactivators (eg: NCOA1, NCOA2, and NCOA3), sequestering the apoptosis signaling protein AIFM1, inhibiting vitamin D signaling, interacting with ARHGDIA to regulate the formation of actin stress fibers, and regulating rho signaling.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197256 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032194 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
↑ Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta. 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.
↑ "Entrez Gene: ANKRD25 ankyrin repeat domain 25".
↑ "Q63ZY3 · KANK2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-24.

External links

Human KANK2 genome location and KANK2 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Zhang Y, Zhang H, Liang J, et al. (2007). "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm". EMBO J. 26 (11): 2645–57. doi:10.1038/sj.emboj.7601710. PMC 1888672. PMID 17476305.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197256 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032194 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-5] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[pmid17996375-6] Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta. 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.

[entrez-7] "Entrez Gene: ANKRD25 ankyrin repeat domain 25".

[8] "Q63ZY3 · KANK2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-24.

KANK2

See also

References

External links

Further reading